Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29882027 | 0.85 | POLB (0.68) | MAPTLMNAPOLBCYP1A2CYP3A4 | |
| SCHEMBL1285787 | 0.85 | POLB (0.68) | MAPTLMNAPOLBCYP1A2CYP3A4 | |
| SCHEMBL3077375 | 0.84 | SIRT1 (0.77) | MAPTPOLBCYP3A4CYP2C19SIRT1 | |
| SCHEMBL26842235 | 0.83 | LMNA (0.67) | MAPTLMNAPOLBCYP1A2CYP3A4 | |
| SCHEMBL262368 | 0.80 | NPC1 (0.58) | MAPTLMNAPOLBSIRT1HPGD | |
| SCHEMBL100732 | 0.80 | CYP1A2 (0.76) | MAPTLMNAPOLBCYP1A2CYP3A4 | |
| SCHEMBL26676262 | 0.80 | MAPT (0.65) | MAPTLMNAPOLBCYP1A2CYP3A4 | |
| SCHEMBL28002036 | 0.78 | NPC1 (0.56) | MAPTLMNAPOLBSIRT1HPGD | |
| Bromide SCHEMBL28425575 | 0.78 | NPC1 (0.56) | MAPTLMNAPOLBSIRT1HPGD | |
| SCHEMBL20036398 | 0.78 | LMNA (0.60) | MAPTLMNAPOLBCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002016357-A2 | QUINUCLIDINE-SUBSTITUTED ARYL MOIETIES FOR TREATMENT OF DISEASE (NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS) | PHARMACIA & UPJOHN COMPANY (US) | 2002-02-28 | — | — | WO | claimed |