Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | EDNRA | P25101 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7707829 | 0.74 | KDM4E (0.35) | KDM4EALDH1A1HPGDSMN1; SMN2SLC22A12 | |
| SCHEMBL7420612 | 0.71 | ALDH1A1 (0.44) | KDM4EALDH1A1HPGDSMN1; SMN2SLC22A12 | |
| SCHEMBL7426960 | 0.67 | ALDH1A1 (0.51) | KDM4EALDH1A1HPGDSMN1; SMN2SLC22A12 | |
| SCHEMBL7421878 | 0.66 | KDM4E (0.41) | KDM4EALDH1A1HPGDSMN1; SMN2SLC22A12 | |
| SCHEMBL7474496 | 0.66 | MEN1 (0.43) | KDM4EALDH1A1HPGDSMN1; SMN2SLC22A12 | |
| SCHEMBL7473906 | 0.61 | ALDH1A1 (0.43) | KDM4EALDH1A1HPGDSMN1; SMN2SLC22A12 | |
| SCHEMBL7476678 | 0.60 | SLC22A12 (0.39) | KDM4EALDH1A1HPGDSMN1; SMN2SLC22A12 | |
| SCHEMBL8843367 | 0.56 | CYP3A4 (0.44) | KDM4EALDH1A1HPGDSMN1; SMN2SLC22A12 | |
| SCHEMBL6306001 | 0.55 | MAPT (0.40) | KDM4EALDH1A1HPGDSMN1; SMN2SLC22A12 | |
| SCHEMBL8215543 | 0.55 | CYP1A2 (0.40) | KDM4EALDH1A1HPGDSMN1; SMN2SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |