Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10784324 | 0.82 | ALDH1A1 (0.40) | NAMPTMAPTL3MBTL1SMN1; SMN2HPGD | |
| SCHEMBL9336190 | 0.78 | NAMPT (0.45) | NAMPTMAPTL3MBTL1SMN1; SMN2HPGD | |
| SCHEMBL8002346 | 0.76 | HPGD (0.50) | TSHRMAPTSMN1; SMN2HPGDHTT | |
| SCHEMBL1663159 | 0.76 | NAMPT (0.44) | NAMPTMAPTL3MBTL1SMN1; SMN2HPGD | |
| SCHEMBL19903800 | 0.73 | HPGD (0.39) | CHRNB2CHRNA4TSHRCHRNA7PGR | |
| SCHEMBL11992345 | 0.72 | MAPT (0.40) | TSHRCHRNA7PGRMAPTL3MBTL1 | |
| SCHEMBL7706728 | 0.71 | NAMPT (0.41) | NAMPTMAPTL3MBTL1HPGDPTGS1 | |
| SCHEMBL12748885 | 0.71 | NPC1 (0.47) | NAMPTTSHRL3MBTL1SMN1; SMN2MAPK1 | |
| SCHEMBL13851546 | 0.71 | NAMPT (0.41) | NAMPTPGRMAPTL3MBTL1HPGD | |
| SCHEMBL25457958 | 0.68 | LMNA (0.35) | CHRNB2CHRNA4TSHRCHRNA7PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9504680-B2 | Pyrrole derivatives as alpha 7 nAChR modulators | LUPIN LIMITED (IN) | 2016-11-29 | — | — | US | disclosed |
| US-9504680-B2 | Pyrrole derivatives as alpha 7 nAChR modulators | LUPIN LIMITED (IN) | 2016-11-29 | — | — | US | disclosed |
| US-9504680-B2 | Pyrrole derivatives as alpha 7 nAChR modulators | LUPIN LIMITED (IN) | 2016-11-29 | — | — | US | disclosed |
| US-20160137600-A1 | Pyrrole Derivatives as Alpha 7 nAChR Modulators | LUPIN LIMITED (IN) | 2016-05-19 | — | — | US | disclosed |
| US-20160137600-A1 | Pyrrole Derivatives as Alpha 7 nAChR Modulators | LUPIN LIMITED (IN) | 2016-05-19 | — | — | US | disclosed |
| US-20160137600-A1 | Pyrrole Derivatives as Alpha 7 nAChR Modulators | LUPIN LIMITED (IN) | 2016-05-19 | — | — | US | disclosed |
| WO-2014203150-A1 | PYRROLE DERIVATIVES AS ALPHA 7 NACHR MODULATORS | LUPIN LIMITED (IN) | 2014-12-24 | — | — | WO | disclosed |
| US-6610730-B2 | Viricides; protease inbhibitor | AGOURON PHARMACEUTICALS, INC. | 2003-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160137600-A1 | Pyrrole Derivatives as Alpha 7 nAChR Modulators | CHRM1, CHRNA7, CHRM2 | NAMPT 2446/4885CHRNB2 21/4885CHRNA4 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.