Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.67 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.67 |
| ▸ | LCK | P06239 | 2/20 | 0.65 |
| ▸ | KDM1A | O60341 | 1/20 | 0.64 |
| ▸ | KDR | P35968 | 6/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.63 |
| ▸ | FLT1 | P17948 | 1/20 | 0.63 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.62 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.62 |
| ▸ | GAK | O14976 | 1/20 | 0.61 |
| ▸ | FBP1 | P09467 | 1/20 | 0.60 |
| ▸ | RET | P07949 | 1/20 | 0.60 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7708517 | 0.92 | EGFR (0.77) | EGFRLCKKDM1AKDRFGFR1 | |
| SCHEMBL20805304 | 0.87 | EGFR (0.77) | EGFRERBB2LCKKDM1AKDR | |
| SCHEMBL30141491 | 0.86 | EGFR (0.78) | EGFRERBB2LCKKDRFLT1 | |
| SCHEMBL242224 | 0.86 | EGFR (0.78) | EGFRERBB2LCKKDRFLT1 | |
| Hydrochloric Acid SCHEMBL8809813 | 0.85 | EGFR (0.76) | EGFRERBB2LCKKDRRIPK2 | |
| SCHEMBL5670824 | 0.85 | EGFR (0.71) | EGFRERBB2LCKKDM1AKDR | |
| SCHEMBL30891782 | 0.85 | EGFR (0.83) | EGFRERBB2LCKKDRFGFR1 | |
| SCHEMBL16660323 | 0.82 | EGFR (0.77) | EGFRERBB2LCKKDM1AKDR | |
| Hydrochloric Acid SCHEMBL8810888 | 0.82 | EGFR (0.68) | EGFRERBB2LCKRIPK2EPHB2 | |
| SCHEMBL8808387 | 0.82 | EGFR (0.75) | EGFRERBB2LCKKDRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476040-B1 | Processes and intermediates for preparing anti-cancer compounds | PFIZER INC. | 2002-11-05 | — | — | US | disclosed |
| EP-1044969-A2 | Processes and intermediates for preparing anti-cancer compounds | Pfizer Products Inc. (US) | 2000-10-18 | — | — | EP | disclosed |