Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.51 |
| ▸ | HTR3A | P46098 | 2/20 | 0.51 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.51 |
| ▸ | HTR3B | O95264 | 1/20 | 0.51 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.51 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6882318 | 0.82 | CHRNA7 (0.54) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL7686026 | 0.80 | CHRNA7 (0.50) | CHRNA7HTR3AKCNH2 | |
| SCHEMBL7061243 | 0.80 | CHRNA7 (0.52) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL2230468 | 0.79 | CHRNA7 (0.54) | CHRNA7 | |
| SCHEMBL2230461 | 0.79 | CHRNA7 (0.54) | CHRNA7 | |
| SCHEMBL2228215 | 0.79 | CHRNA7 (0.64) | CHRNA7HTR3AKCNH2 | |
| SCHEMBL7281094 | 0.79 | CHRNA7 (0.64) | CHRNA7HTR3AKCNH2 | |
| SCHEMBL2228214 | 0.79 | CHRNA7 (0.64) | CHRNA7HTR3AKCNH2 | |
| SCHEMBL7697552 | 0.79 | HTR3E (0.53) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL7699687 | 0.77 | CHRNA7 (0.50) | CHRNA7HTR3AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479510-B2 | N-((2S,3R)-2-METHYL-1-AZABICYCLO(2.2.2)OCT-3-YL)-4-(4-HYDROXYP HENOXY)- BENZAMIDE FOR EXAMPLE; TREATING DISEASES OF THE ALPHA-7-NICOTINIC ACETYLCHOLINE RECEPTOR I.E. SCHIZOPHRENIA, OR PSYCHOSIS | PHARMACIA & UPJOHN COMPANY | 2002-11-12 | — | — | US | claimed |