Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CASR | P41180 | 1/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6859136 | 0.88 | POLB (0.50) | POLBCASRSIRT3TP53KMT2A | |
| SCHEMBL7713876 | 0.84 | POLB (0.43) | POLBCASRTP53KMT2AMAPT | |
| SCHEMBL7711555 | 0.84 | TSHR (0.39) | CASRTSHR | |
| SCHEMBL7705262 | 0.81 | TSHR (0.47) | TP53KMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL7708679 | 0.74 | CASR (0.47) | POLBCASRGAATSHR | |
| SCHEMBL6860561 | 0.74 | CASR (0.47) | POLBCASRGAATSHR | |
| SCHEMBL7711490 | 0.72 | SMN1; SMN2 (0.38) | POLBTP53KMT2AMAPTMEN1 | |
| SCHEMBL6862489 | 0.71 | POLB (0.47) | POLBCASRKMT2AMAPTGAA | |
| SCHEMBL30929581 | 0.69 | RORC (0.49) | TP53KMT2AMAPTMEN1LMNA | |
| SCHEMBL30929557 | 0.69 | RORC (0.49) | TP53KMT2AMAPTMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6794385-B2 | ANTITUMOR AGENTS; ANTICANCER AGENTS; OSTEOPOROSIS | PHARMACIA & UPJOHN, S.P.A. (IT) | 2004-09-21 | — | — | US | disclosed |
| US-6794385-B2 | ANTITUMOR AGENTS; ANTICANCER AGENTS; OSTEOPOROSIS | PHARMACIA & UPJOHN, S.P.A. (IT) | 2004-09-21 | — | — | US | disclosed |