Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 10/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6860701 | 0.88 | SIRT1 (0.51) | SIRT1SIRT2BRD4 | |
| SCHEMBL7711823 | 0.84 | SIRT1 (0.52) | TSHRSIRT1SIRT2ALDH1A1SMN1; SMN2 | |
| SCHEMBL7711555 | 0.84 | TSHR (0.39) | TSHR | |
| SCHEMBL16843718 | 0.83 | MTNR1A (0.52) | SIRT1BRD4MEN1TP53MAPT | |
| SCHEMBL18144508 | 0.83 | MTNR1A (0.52) | SIRT1BRD4MEN1TP53MAPT | |
| SCHEMBL7708663 | 0.81 | POLB (0.46) | TSHRSIRT1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL16823431 | 0.81 | RORC (0.60) | — | |
| SCHEMBL18143292 | 0.81 | RORC (0.60) | — | |
| SCHEMBL18168933 | 0.80 | SIRT1 (0.46) | SIRT1SIRT2BRD4 | |
| SCHEMBL18168893 | 0.80 | SIRT1 (0.46) | SIRT1SIRT2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6794385-B2 | ANTITUMOR AGENTS; ANTICANCER AGENTS; OSTEOPOROSIS | PHARMACIA & UPJOHN, S.P.A. (IT) | 2004-09-21 | — | — | US | disclosed |
| US-6794385-B2 | ANTITUMOR AGENTS; ANTICANCER AGENTS; OSTEOPOROSIS | PHARMACIA & UPJOHN, S.P.A. (IT) | 2004-09-21 | — | — | US | disclosed |