Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | STAT3 | P40763 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7703244 | 0.89 | DPP4 (0.47) | SMN1; SMN2NPC1ALDH1A1RAB9AKDM4E | |
| SCHEMBL7423524 | 0.88 | ALDH1A1 (0.53) | SMN1; SMN2NPC1ALDH1A1RAB9AKDM4E | |
| SCHEMBL7431382 | 0.84 | NPC1 (0.52) | SMN1; SMN2NPC1ALDH1A1RAB9AKDM4E | |
| SCHEMBL7709135 | 0.82 | ADORA2A (0.58) | SMN1; SMN2HPGDKMT2A | |
| SCHEMBL7705877 | 0.82 | SMN1; SMN2 (0.41) | SMN1; SMN2NPC1ALDH1A1RAB9AKDM4E | |
| SCHEMBL7427474 | 0.81 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1ALDH1A1RAB9AKDM4E | |
| SCHEMBL7711838 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1ALDH1A1RAB9AKDM4E | |
| SCHEMBL7709161 | 0.80 | ADORA2A (0.53) | SMN1; SMN2NPC1ALDH1A1RAB9AKDM4E | |
| SCHEMBL7708891 | 0.80 | KDM4E (0.49) | SMN1; SMN2NPC1ALDH1A1RAB9AKDM4E | |
| SCHEMBL7709147 | 0.79 | KDR (0.48) | SMN1; SMN2NPC1ALDH1A1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355653-B1 | DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS | HOFFMANN-LA ROCHE INC. | 2002-03-12 | — | — | US | disclosed |