Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8037300 | 1.00 | TSHR (0.43) | TSHRCYP1A2CYP2C19MAPTPKM | |
| SCHEMBL8048116 | 1.00 | TSHR (0.43) | TSHRCYP1A2CYP2C19MAPTPKM | |
| SCHEMBL8049334 | 0.85 | TSHR (0.45) | TSHRCYP1A2CYP2C19MAPTPKM | |
| SCHEMBL8037835 | 0.85 | TSHR (0.45) | TSHRCYP1A2CYP2C19MAPTPKM | |
| SCHEMBL10581361 | 0.84 | PIN1 (0.46) | TSHRCYP1A2MAPTBLMPIN1 | |
| SCHEMBL8055172 | 0.82 | HSD17B1 (0.44) | MAPT | |
| SCHEMBL8047432 | 0.82 | HSD17B1 (0.44) | MAPT | |
| SCHEMBL25598732 | 0.81 | MEN1 (0.45) | TSHRMAPTALDH1A1HTT | |
| SCHEMBL8055202 | 0.81 | MEN1 (0.42) | TSHRMAPTALDH1A1KDM4EHTT | |
| SCHEMBL2064898 | 0.81 | MEN1 (0.42) | TSHRMAPTALDH1A1KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369110-B1 | PROPHYLACTIC AGENT FOR DISEASES CAUSED BY THE ACCELERATION OF THE SODIUM/PROTON EXCHANGE TRANSPORT SYSTEM | SUMITOMO PHARMACEUTICALS COMPANY (JP) | 2002-04-09 | — | — | US | disclosed |
| EP-1083166-A1 | NOVEL SUBSTITUTED GUANIDINE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-03-14 | — | — | EP | disclosed |