Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.30 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.30 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.30 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14383723 | 1.00 | HTR2A (0.37) | HTR2AHRH1ALDH1A1TSHRTDP1 | |
| SCHEMBL21164180 | 0.82 | ALDH1A1 (0.45) | HTR2AHRH1ALDH1A1TSHRTDP1 | |
| SCHEMBL24744131 | 0.80 | ALDH1A1 (0.50) | HTR2AHRH1ALDH1A1TSHRTDP1 | |
| SCHEMBL23902118 | 0.77 | — | — | |
| SCHEMBL24882571 | 0.77 | DNM1 (0.38) | HTR2AHRH1ALDH1A1TSHRTDP1 | |
| SCHEMBL25978414 | 0.77 | HTR2A (0.34) | HTR2AHRH1ALDH1A1TSHRTDP1 | |
| SCHEMBL25604411 | 0.76 | TDP1 (0.39) | TDP1CA12CA2CA3CA4 | |
| SCHEMBL23846278 | 0.75 | HTR2A (0.37) | HTR2AHRH1ALDH1A1TSHRTDP1 | |
| SCHEMBL12259439 | 0.75 | HTR2A (0.37) | HTR2AHRH1ALDH1A1TSHRTDP1 | |
| SCHEMBL24121393 | 0.75 | PIK3CD (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11155557-B2 | Pyrazolopyrimidine compounds and methods of use thereof | GENENTECH, INC. (US) | 2021-10-26 | — | — | US | disclosed |
| US-20190345165-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2019-11-14 | — | — | US | disclosed |
| WO-2011136192-A1 | IMIDAZO[1,2-a]PYRIDINE DERIVATIVE | アステラス製薬株式会社 (JP) | 2011-11-03 | — | — | WO | disclosed |
| WO-2008080938-A1 | USE 2-SUBSTITUTED PYRIDINES FOR CANCER TREATMENT | BASF SE (DE) | 2008-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11155557-B2 | Pyrazolopyrimidine compounds and methods of use thereof | JAK2, JAK1, JAK3 | HTR2A 4677/4885HRH1 2052/4885ALDH1A1 819/4885 |
| US-20190345165-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | JAK2, JAK1, JAK3 | HTR2A 4677/4885HRH1 2052/4885ALDH1A1 819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.