Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 14/20 | 0.44 |
| ▸ | FNTA | P49354 | 2/20 | 0.36 |
| ▸ | FNTB | P49356 | 2/20 | 0.36 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7709318 | 1.00 | GPR119 (0.44) | GPR119FNTAFNTBPGGT1BKCNH2 | |
| SCHEMBL7717481 | 0.83 | CYP11B1 (0.38) | FNTAFNTBPGGT1BKCNH2CACNA1H | |
| SCHEMBL7715398 | 0.83 | CYP11B1 (0.38) | FNTAFNTBPGGT1BKCNH2CACNA1H | |
| SCHEMBL7721388 | 0.83 | FNTA (0.44) | FNTAFNTBPGGT1BKCNH2 | |
| SCHEMBL7721386 | 0.83 | FNTA (0.44) | FNTAFNTBPGGT1BKCNH2 | |
| SCHEMBL7168713 | 0.77 | FNTA (0.45) | GPR119FNTAFNTBPGGT1BCACNA1H | |
| SCHEMBL7717611 | 0.71 | FNTA (0.40) | FNTAFNTBPGGT1BKCNH2 | |
| SCHEMBL7717612 | 0.71 | FNTA (0.40) | FNTAFNTBPGGT1BKCNH2 | |
| SCHEMBL7183733 | 0.71 | CYP11B1 (0.46) | FNTAFNTBPGGT1BKCNH2CACNA1H | |
| SCHEMBL8097403 | 0.67 | CYP11B1 (0.49) | GPR119FNTAFNTBPGGT1BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441017-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1214326-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001018006-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |