Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.46 |
| ▸ | CTSD | P07339 | 5/20 | 0.42 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7715214 | 0.86 | BACE1 (0.57) | BACE1CTSDBACE2 | |
| SCHEMBL7704786 | 0.81 | BACE1 (0.56) | BACE1CTSDBACE2 | |
| SCHEMBL7709581 | 0.81 | BACE1 (0.52) | BACE1CTSDBACE2 | |
| SCHEMBL7710755 | 0.79 | BACE1 (0.44) | BACE1CTSDBACE2 | |
| SCHEMBL7712129 | 0.74 | BACE1 (0.41) | BACE1CTSDBACE2 | |
| SCHEMBL7712107 | 0.71 | BACE1 (0.77) | BACE1CTSDBACE2 | |
| SCHEMBL12593022 | 0.70 | CTSD (0.74) | BACE1CTSD | |
| SCHEMBL2572112 | 0.68 | BACE1 (0.73) | BACE1CTSDBACE2 | |
| SCHEMBL2572115 | 0.68 | BACE1 (0.73) | BACE1CTSDBACE2 | |
| SCHEMBL12592758 | 0.68 | CTSD (0.59) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130741-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-20 | — | — | WO | disclosed |