Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19585633 | 0.80 | MAPK1 (0.49) | GAARXFP1PSMD14TRPM8ALDH1A1 | |
| SCHEMBL7706427 | 0.77 | ALDH1A1 (0.46) | GAARXFP1PSMD14TRPM8ALDH1A1 | |
| SCHEMBL31215206 | 0.77 | KDM4E (0.49) | GAARXFP1PSMD14TRPM8ALDH1A1 | |
| SCHEMBL7706361 | 0.77 | HCRTR2 (0.62) | GAATRPM8ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL18549701 | 0.76 | KDM4E (0.46) | GAARXFP1PSMD14TRPM8ALDH1A1 | |
| SCHEMBL18549674 | 0.75 | ALDH1A1 (0.44) | GAARXFP1PSMD14TRPM8ALDH1A1 | |
| SCHEMBL18549636 | 0.74 | ALDH1A1 (0.49) | GAARXFP1PSMD14ALDH1A1MAPT | |
| SCHEMBL15492956 | 0.74 | ALDH1A1 (0.45) | GAARXFP1PSMD14TRPM8ALDH1A1 | |
| SCHEMBL2593528 | 0.74 | PPARG (0.41) | ALDH1A1MAPTTSHRL3MBTL1KDM4E | |
| SCHEMBL31215231 | 0.70 | ALDH1A1 (0.52) | GAAALDH1A1MAPTTSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |