Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 16/20 | 0.69 |
| ▸ | RXRB | P28702 | 13/20 | 0.69 |
| ▸ | RXRG | P48443 | 13/20 | 0.69 |
| ▸ | RARB | P10826 | 6/20 | 0.54 |
| ▸ | RARA | P10276 | 5/20 | 0.54 |
| ▸ | RARG | P13631 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8116214 | 0.96 | RXRA (0.69) | RXRARXRBRXRGRARBRARA | |
| SCHEMBL8116675 | 0.92 | RXRA (0.70) | RXRARXRBRXRGRARBRARA | |
| SCHEMBL8113512 | 0.87 | RXRA (0.56) | RXRARXRBRXRGRARBRARA | |
| SCHEMBL8122280 | 0.87 | RXRA (0.67) | RXRARXRBRXRGRARBRARA | |
| SCHEMBL8116841 | 0.86 | RXRA (0.65) | RXRARXRBRXRGRARBRARA | |
| SCHEMBL8116011 | 0.86 | RXRA (0.65) | RXRARXRBRXRGRARBRARA | |
| SCHEMBL8115665 | 0.85 | RXRA (0.53) | RXRARXRBRXRGRARBRARA | |
| SCHEMBL8114654 | 0.83 | RXRA (0.67) | RXRARXRBRXRGRARBRARA | |
| SCHEMBL7706907 | 0.82 | RARA (0.59) | RXRARXRBRXRGRARBRARA | |
| SCHEMBL17049085 | 0.82 | RXRA (1.00) | RXRARXRBRXRGRARBRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228042-A2 | TETRAHYDROQUINOLINE DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | Allergan Sales, Inc. (US) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001012606-A2 | TETRAHYDROQUINOLINE DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN SALES, INC. (US) | 2001-02-22 | — | — | WO | disclosed |
| US-6127382-A | AN ANTIPROLIFERATIVE AGENT FOR TREATING SKIN-RELATED DISEASES, AN ANTITUMOR AGENT TREATING CANCER, AN ANTIINFLAMMATORY AGENT TREATING PULMONARY FIBROSIS, ILEITIS, COLITIS AND KROHN'S DISEASE | ALLERGAN SALES, INC. (US) | 2000-10-03 | — | — | US | disclosed |