Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7712897 | 0.92 | PTGDR2 (0.42) | NPY1RNPY2RPTGDR2PDE4BPTPN1 | |
| SCHEMBL7802721 | 0.85 | PTPN1 (0.37) | NPY1RNPY2RPDE4BDHFRPTPN1 | |
| SCHEMBL28897169 | 0.84 | PDE4B (0.48) | NPY1RNPY2RPDE4BPTPN1 | |
| SCHEMBL30124787 | 0.84 | PDE4B (0.48) | NPY1RNPY2RPDE4BPTPN1 | |
| SCHEMBL2891959 | 0.84 | PDE4B (0.43) | NPY1RNPY2RPDE4BPTPN1 | |
| SCHEMBL30601751 | 0.84 | PDE4B (0.48) | NPY1RNPY2RPDE4BPTPN1 | |
| SCHEMBL27404540 | 0.84 | MAPK1 (0.38) | NPY1RNPY2RPDE4BDHFRPTPN1 | |
| SCHEMBL16035389 | 0.82 | ALDH1A1 (0.39) | NPY1RNPY2RPDE4BDHFRPTPN1 | |
| SCHEMBL12429186 | 0.82 | LMNA (0.35) | NPY1RNPY2RPDE4BDHFRPTPN1 | |
| SCHEMBL7710565 | 0.82 | ALDH1A1 (0.40) | PDE4BKDM4CLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369100-B1 | Method for inhibiting gene expression promoted by AP1 protein with RARβ selective retinoids and method for treatment of diseases and conditions with such retinoids | ALLERGAN SALES, INC. | 2002-04-09 | — | — | US | disclosed |
| US-6025388-A | Method for inhibiting gene expression promoted by AP1 protein with RARβ selective retinoids and method for treatment of diseases and conditions with such retinoids | ALLERGAN SALES, INC. (US) | 2000-02-15 | — | — | US | disclosed |
| US-5847160-A | Acetylenes disubstituted with 2-tetrahydropyranoxy-aryl and aryl of heteroaryl groups having retinoid-like biological activity | ALLERGAN (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0828490-A1 | RAR-beta SELECTIVE RETINOID COMPOUNDS FOR INHIBITING GENE EXPRESSION PROMOTED BY AP1 PROTEIN AND THEIR USE IN THERAPY | Allergan (US) | 1998-03-18 | — | — | EP | disclosed |
| US-5698700-A | Acetylenes disubstituted with 2-tetrahydropyranoxyaryl and aryl or heteroaryl groups having retinoid-like biological activity | ALLERGAN (US) | 1997-12-16 | — | — | US | disclosed |
| WO-1996033716-A1 | RARβ SELECTIVE RETINOID COMPOUNDS FOR INHIBITING GENE EXPRESSION PROMOTED BY AP1 PROTEIN AND THEIR USE IN THERAPY | ALLERGAN (US) | 1996-10-31 | — | — | WO | disclosed |
| WO-1996020938-A1 | ACETYLENES DISUBSTITUTED WITH 2-TETRAHYDROPYRANOXYARYL AND ARYL OR HETEROARYL GROUPS HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN (US) | 1996-07-11 | — | — | WO | disclosed |
| US-5534641-A | Acetylenes disubstituted with 2-tetrahydropyranoxyaryl and aryl or heteroaryl groups having retinoid-like biological activity | ALLERGAN | 1996-07-09 | — | — | US | disclosed |
| US-5498795-A | ANTITUMOR AGENTS, SKIN DISORDERS, ATHEROSCLEROSIS, PROSTATE CANCER AND AUTOIMMUNE DISEASES | ALLERGAN, INC. (US) | 1996-03-12 | — | — | US | disclosed |