Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 9/20 | 0.64 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.64 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | GMNN | O75496 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10375898 | 0.82 | CYSLTR1 (0.67) | CYSLTR1CYSLTR2GPBAR1MAPK1ALOX5 | |
| SCHEMBL10632284 | 0.80 | CYSLTR1 (0.75) | CYSLTR1CYSLTR2GPBAR1MAPK1ALOX5 | |
| SCHEMBL10551528 | 0.80 | CYSLTR1 (0.60) | CYSLTR1CYSLTR2GPBAR1MAPK1ALOX5 | |
| SCHEMBL10375899 | 0.79 | CYSLTR1 (0.68) | CYSLTR1CYSLTR2GPBAR1ALOX5 | |
| Ritolukast SCHEMBL38043 | 0.79 | CYSLTR1 (1.00) | CYSLTR1CYSLTR2GPBAR1MAPK1TP53 | |
| SCHEMBL10556228 | 0.78 | CYSLTR1 (0.64) | CYSLTR1CYSLTR2GPBAR1MAPK1ALOX5 | |
| SCHEMBL10551572 | 0.78 | CYSLTR1 (0.61) | CYSLTR1CYSLTR2GPBAR1MAPK1ALOX5 | |
| SCHEMBL10636181 | 0.78 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2GPBAR1MAPK1ALOX5 | |
| SCHEMBL10635784 | 0.78 | CYSLTR1 (0.74) | CYSLTR1CYSLTR2GPBAR1MAPK1ALOX5 | |
| SCHEMBL10552847 | 0.78 | CYSLTR1 (0.63) | CYSLTR1CYSLTR2GPBAR1MAPK1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358981-B1 | FOR THERAPY OF CENTRAL NERVOUS SYSTEM (CNS) DISORDERS | ELI LILLY AND COMPANY | 2002-03-19 | — | — | US | claimed |
| US-4876346-A | LIPOXYGENASE INHIBITORS; ANTIALLERGENS, ANTIINFLAMMATORY AGENTS, RHINITIS, ASTHMA | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-10-24 | — | — | US | claimed |
| US-4876346-A | LIPOXYGENASE INHIBITORS; ANTIALLERGENS, ANTIINFLAMMATORY AGENTS, RHINITIS, ASTHMA | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-10-24 | — | — | US | disclosed |