Ritolukast

Ritolukast

SCHEMBL38043

O=S(=O)(Nc1cccc(OCc2ccc3ccccc3n2)c1)C(F)(F)F

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYSLTR1 Q9Y271 10/20 1.00
CYSLTR2 Q9NS75 5/20 1.00
KDM4E B2RXH2 1/20 0.56
MEN1 O00255 1/20 0.56
NPC1 O15118 1/20 0.56
ALDH1A1 P00352 1/20 0.56
LMNA P02545 1/20 0.56
TP53 P04637 1/20 0.56
CYP1A2 P05177 1/20 0.56
CYP3A4 P08684 1/20 0.56
CYP2D6 P10635 1/20 0.56
MAPT P10636 1/20 0.56
CYP2C9 P11712 1/20 0.56
TSHR P16473 1/20 0.56
MAPK1 P28482 1/20 0.56
CYP2C19 P33261 1/20 0.56
THPO P40225 1/20 0.56
BLM P54132 1/20 0.56
PMP22 Q01453 1/20 0.56
KMT2A Q03164 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10685299 0.89 CYSLTR1 (0.80) CYSLTR1CYSLTR2PDE10A
SCHEMBL10755026 0.84 CYSLTR1 (0.72) CYSLTR1CYSLTR2KDM4EMEN1NPC1
SCHEMBL10377922 0.83 CYSLTR1 (0.72) CYSLTR1CYSLTR2KDM4EMEN1NPC1
SCHEMBL10655893 0.83 CYSLTR1 (0.70) CYSLTR1CYSLTR2KDM4EMEN1NPC1
Hydrochloric Acid SCHEMBL9447146 0.82 CYSLTR1 (0.69) CYSLTR1CYSLTR2KDM4EMEN1NPC1
SCHEMBL9721977 0.81 CYSLTR1 (0.69) CYSLTR1CYSLTR2KDM4EMEN1NPC1
SCHEMBL14021761 0.81 CYSLTR1 (0.68) CYSLTR1CYSLTR2GPBAR1PDE10A
SCHEMBL10375899 0.81 CYSLTR1 (0.68) CYSLTR1CYSLTR2GPBAR1
SCHEMBL9447225 0.81 CYSLTR1 (0.67) CYSLTR1CYSLTR2KDM4EMEN1NPC1
SCHEMBL9715790 0.81 CYSLTR1 (0.67) CYSLTR1CYSLTR2KDM4EMEN1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 546 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1931320-B1 MICROPARTICLES WITH MODIFIED RELEASE OF AT LEAST ONE ACTIVE PRINCIPLE AND ORAL DOSAGE FORM COMPRISING THE SAME FLAMEL IRELAND LTD (IE) 2022-06-15 EP claimed
EP-2575786-B1 PROCESS FOR DRY POWDER FORMULATIONS SIMA PATENT VE LISANSLAMA HIZMETLERI LTD STI (TR) 2017-11-15 EP claimed
US-9259376-B2 Process for dry powder formulations SIMA PATENT VE LISANSLAMA HIZMETLERI LTD. STI. (TR) 2016-02-16 US claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20130202778-A1 PROCESS FOR DRY POWDER FORMULATIONS SIMA PATENT VE LISANSLAMA HIZMETLERI LTD. STI. (TR) 2013-08-08 US claimed
EP-2575786-A2 PROCESS FOR DRY POWDER FORMULATIONS Bilgic, Mahmut (TR) 2013-04-10 EP claimed
EP-2563364-A1 COMBINATION OF CARMOTEROL AND FLUTICASONE FOR USE IN THE TREATMENT RESPIRATORY DISEASES Bilgic, Mahmut (TR) 2013-03-06 EP claimed
WO-2013009271-A1 NEW IMPROVED DRY POWDER FORMULATION BILGIC MAHMUT (TR) 2013-01-17 WO claimed
US-8268352-B2 Modified release composition for highly soluble drugs TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-18 US claimed
US-8263125-B2 Dosage form for high dose-high solubility active ingredients that provides for immediate release and modified release of the active ingredients TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-11 US claimed
WO-2007036671-A2 MICROPARTICLES WITH MODIFIED RELEASE OF AT LEAST ONE ACTIVE PRINCIPLE AND ORAL GALENIC FORM COMPRISING SAME FLAMEL TECHNOLOGIES (FR) 2007-04-05 WO claimed
US-20060024365-A1 Novel dosage form VAYA NAVIN 2006-02-02 US claimed
US-20060018933-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
US-20060018934-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
US-20030176421-A1 PROKINETIC AGENTS FOR TREATING GASTRIC HYPOMOTILITY AND RELATED DISORDERS WATSON JOHN W (US) 2003-09-18 US claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 EP claimed
EP-0469477-B1 Antiallergic combination HOFFMANN LA ROCHE (CH) 1995-09-20 EP claimed
EP-0469477-A1 Antiallergic combination F. HOFFMANN-LA ROCHE AG (CH) 1992-02-05 EP claimed
EP-0232954-A2 Heterocyclic sulphonamides AMERICAN HOME PRODUCTS CORPORATION (US) 1987-08-19 EP claimed
US-4675405-A Quinoline compounds as antiallergic and antithrombotic agents AMERICAN HOME PRODUCTS CORPORATION (US) 1987-06-23 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030176421-A1 PROKINETIC AGENTS FOR TREATING GASTRIC HYPOMOTILITY AND RELATED DISORDERS OPRM1, OPRK1, OPRD1 CYSLTR1 4303/4885CYSLTR2 3991/4885KDM4E 1698/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.