⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL359530 | 1.00 | — | — | |
| SCHEMBL799528 | 1.00 | — | — | |
| SCHEMBL3939409 | 0.88 | ADH1B (0.52) | — | |
| SCHEMBL769923 | 0.86 | ADH1B (0.59) | — | |
| SCHEMBL3756245 | 0.81 | — | — | |
| SCHEMBL14231203 | 0.79 | ADH1B (0.58) | — | |
| Hydrochloric Acid SCHEMBL27460137 | 0.77 | KAT2B (0.33) | — | |
| SCHEMBL23173285 | 0.75 | ADH1B (0.56) | — | |
| SCHEMBL172647 | 0.75 | ADH1B (0.40) | — | |
| SCHEMBL24165493 | 0.75 | KDM1A (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108699106-A | Novel trifluoromethyl propanamide derivative as HTRA1 inhibitor | 豪夫迈·罗氏有限公司 | 2018-10-23 | — | — | CN | claimed |
| CN-108699035-A | Noval chemical compound | 特殊治疗有限公司 | 2018-10-23 | — | — | CN | claimed |
| EP-3992191-A1 | IMIDAZO[4,5-C]QUINOLINE COMPOUNDS AND THEIR USE AS ATM KINASE INHIBITORS | Deutsches Krebsforschungszentrum (DE) | 2022-05-04 | — | — | EP | disclosed |
| EP-3193604-B1 | SUBSTITUTED N-(PYRROLIDIN-3-YL)ISOXAZOLE-3-CARBOXAMIDE COMPOUNDS | EPIZYME INC (US) | 2021-06-16 | — | — | EP | disclosed |
| CN-110506039-A | Compounds and methods for targeted degradation of androgen receptor | ARVINAS INC | 2019-11-26 | — | — | CN | disclosed |
| CN-108699106-A | Novel trifluoromethyl propanamide derivative as HTRA1 inhibitor | 豪夫迈·罗氏有限公司 | 2018-10-23 | — | — | CN | disclosed |
| CN-108699035-A | Noval chemical compound | 特殊治疗有限公司 | 2018-10-23 | — | — | CN | disclosed |
| CN-105121430-B | Conditioning agent for treating the LADA orphan receptor γ related to the biostearin of inflammatory disease (ROR γ) | 葛兰素集团有限公司 | 2017-06-16 | — | — | CN | disclosed |
| WO-2013120980-A1 | TRICYCLIC COMPOUNDS AND METHODS OF USE THEREFOR | F. HOFFMANN-LA ROCHE AG (CH) | 2013-08-22 | — | — | WO | disclosed |
| US-20120070409-A1 | TETRACYCLIC FUSED HETEROCYCLIC COMPOUND AND USE THEREOF AS HCV POLYMERASE INHIBITOR | JAPAN TOBACCO INC. (JP) | 2012-03-22 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| EP-2206715-A1 | Fused heterotetracyclic compounds and use thereof as hcv polymerase inhibitor | Japan Tobacco, Inc. (JP) | 2010-07-14 | — | — | EP | disclosed |
| US-7659263-B2 | Thienopyrrole compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2010-02-09 | — | — | US | disclosed |
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |
| EP-1719773-B1 | FUSED HETEROTETRACYCLIC COMPOUNDS AND USE TEHREOF AS HCV POLYMERASE INHIBITOR | JAPAN TOBACCO INC (JP) | 2009-04-15 | — | — | EP | disclosed |
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |
| US-20070049593-A1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2007-03-01 | — | — | US | disclosed |
| EP-1719773-A1 | FUSED HETEROTETRACYCLIC COMPOUNDS AND USE TEHREOF AS HCV POLYMERASE INHIBITOR | Japan Tobacco, Inc. (JP) | 2006-11-08 | — | — | EP | disclosed |
| US-20060167246-A1 | Thienopyrrole compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2006-07-27 | — | — | US | disclosed |