Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA7 | P43166 | 2/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22751884 | 0.84 | KDM4E (0.47) | KCNA5TSHRLMNAMAPTHPGD | |
| SCHEMBL12820105 | 0.83 | ALDH1A1 (0.41) | KCNA5TSHRMAPTHPGDHTT | |
| SCHEMBL9863542 | 0.81 | AKR1B1 (0.55) | AKR1B1POLBMAPK1HSPA5 | |
| SCHEMBL7898052 | 0.81 | KMT2A (0.46) | AKR1B1CA12CA1CA7CA14 | |
| SCHEMBL10509525 | 0.78 | NPC1 (0.51) | KCNA5TSHRLMNARAB9A | |
| SCHEMBL4657688 | 0.78 | POLB (0.49) | POLBTSHRHPGDRAB9A | |
| SCHEMBL30311288 | 0.75 | AKR1B1 (0.61) | AKR1B1CA12CA1CA7CA14 | |
| SCHEMBL392976 | 0.75 | AKR1B1 (0.61) | AKR1B1CA12CA1CA7CA14 | |
| SCHEMBL765424 | 0.74 | AKR1B1 (0.42) | AKR1B1POLBMAPK1EGFRTSHR | |
| SCHEMBL14047007 | 0.74 | AKR1B1 (0.42) | AKR1B1POLBMAPK1EGFRTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376512-B1 | FOR TREATING PHYSIOLOGICAL CONDITION IN PATIENT WHEREIN SAID CONDITION IS ASSOCIATED WITH A PHYSIOLOGICALLY DETRIMENTAL LEVELS OF INSULIN, GLUCOSE, FREE FATTY ACIDS, OR TRIGLYCERIDES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-04-23 | — | — | US | disclosed |