Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | POLB | P06746 | 3/20 | 1.00 |
| ▸ | ERCC1 | P07992 | 2/20 | 1.00 |
| ▸ | FEN1 | P39748 | 2/20 | 1.00 |
| ▸ | ERCC4 | Q92889 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | TYMS | P04818 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | XBP1 | P17861 | 2/20 | 0.59 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9127705 | 0.82 | KDM4E (0.70) | MAPTPOLBERCC1FEN1ERCC4 | |
| SCHEMBL16213400 | 0.82 | KDM4E (1.00) | MAPTPOLBERCC1FEN1ERCC4 | |
| SCHEMBL11768082 | 0.82 | KDM4E (0.70) | MAPTPOLBERCC1FEN1ERCC4 | |
| SCHEMBL7706682 | 0.81 | MAPT (0.69) | MAPTPOLBERCC1FEN1ERCC4 | |
| SCHEMBL11712317 | 0.81 | ALDH1A1 (0.68) | MAPTPOLBERCC1FEN1ERCC4 | |
| SCHEMBL10267893 | 0.81 | ALDH1A1 (0.77) | MAPTPOLBERCC1FEN1ERCC4 | |
| SCHEMBL7709255 | 0.79 | MAPT (0.65) | MAPTPOLBERCC1FEN1ERCC4 | |
| SCHEMBL7735555 | 0.79 | KDM4E (0.68) | MAPTPOLBERCC1FEN1ERCC4 | |
| SCHEMBL11778537 | 0.79 | FEN1 (0.65) | MAPTPOLBERCC1FEN1ERCC4 | |
| SCHEMBL3437810 | 0.79 | TYMS (0.71) | MAPTPOLBERCC1FEN1ERCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362181-B1 | BACTERICIDES; ENZYME INHIBITORS; ANTITUMOR AGENTS | WARNER-LAMBERT COMPANY | 2002-03-26 | — | — | US | claimed |
| EP-0939754-A2 | N-OXY-NAPHTHALIMIDES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1999-09-08 | — | — | EP | claimed |
| WO-1998019648-A2 | N-OXY-NAPHTHALIMIDES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1998-05-14 | — | — | WO | claimed |
| US-6362181-B1 | BACTERICIDES; ENZYME INHIBITORS; ANTITUMOR AGENTS | WARNER-LAMBERT COMPANY | 2002-03-26 | — | — | US | disclosed |
| US-6177423-B1 | N-(HYDROXY OR PROTECTED HYDROXY)-BENZO(DE)ISOQUINOLINE-1,3-DIONE DERIVATIVES; BACTERIAL DNA GYRASE AND DNA TOPOISOMERASE INHIBITORS USEFUL FOR ANTIBACTERIAL AGENTS HAVING REDUCED DRUG RESISTANCE AND REDUCED SIDE EFFECTS | WARNER-LAMBERT COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0939754-A2 | N-OXY-NAPHTHALIMIDES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1999-09-08 | — | — | EP | disclosed |
| WO-1998019648-A2 | N-OXY-NAPHTHALIMIDES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1998-05-14 | — | — | WO | disclosed |