Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | MTOR | P42345 | 2/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.61 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.61 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.61 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.56 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.56 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.56 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CDA | P32320 | 1/20 | 0.54 |
| ▸ | GMNN | O75496 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.51 |
| ▸ | THPO | P40225 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7714785 | 1.00 | LMNA (0.61) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL2779073 | 0.86 | LMNA (0.68) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL19305873 | 0.86 | LMNA (0.68) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL31685517 | 0.83 | P2RY2 (0.66) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL31685423 | 0.83 | LMNA (0.57) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL25196517 | 0.83 | P2RY2 (0.72) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL18503539 | 0.81 | LMNA (0.72) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL18720728 | 0.81 | LMNA (0.72) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL18512923 | 0.81 | LMNA (0.72) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL16229237 | 0.81 | LMNA (0.72) | LMNAMTORTHRBMDM2NCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369040-B1 | INCORPORATING A COMPLEMENTARY SEQUENCES FOR HERPES, PAPILLOMA AND OTHER VIRUSES | ISIS PHARMACEUTICALS, INC. | 2002-04-09 | — | — | US | disclosed |
| US-6060592-A | Pyrimidine nucleoside compounds and oligonucleoside compounds containing same | ISIS PHARMACEUTICALS, INC. (US) | 2000-05-09 | — | — | US | disclosed |