SCHEMBL7712583

SCHEMBL7712583

COc1ccc(C=O)cc1OC(=O)C(C)(C)C

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 10/20 0.64
TSHR P16473 1/20 0.64
HPGD P15428 2/20 0.54
TDP1 Q9NUW8 2/20 0.54
AOX1 Q06278 1/20 0.54
TRIM24 O15164 1/20 0.54
ALDH5A1 P51649 1/20 0.54
ABAT P80404 1/20 0.54
TRIM33 Q9UPN9 1/20 0.54
KMT2A Q03164 1/20 0.54
POLB P06746 1/20 0.52
FDPS P14324 1/20 0.51
KDM4E B2RXH2 2/20 0.51
MAPT P10636 2/20 0.51
SMN1; SMN2 Q16637 3/20 0.49
TTR P02766 1/20 0.48
GAA P10253 1/20 0.46
ALOX15 P16050 1/20 0.46
MAPK1 P28482 1/20 0.46
HSD17B10 Q99714 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22021776 0.94 ALDH1A1 (0.64) ALDH1A1TSHRHPGDTDP1AOX1
SCHEMBL19663397 0.83 ALDH1A1 (0.60) ALDH1A1TSHRHPGDTDP1AOX1
SCHEMBL871742 0.82 ALDH1A1 (0.70) ALDH1A1TSHRHPGDTDP1AOX1
SCHEMBL10919494 0.81 POLB (0.47) ALDH1A1TSHRHPGDPOLBFDPS
SCHEMBL2951944 0.80 ALDH1A1 (0.62) ALDH1A1TSHRHPGDTDP1AOX1
3,4-Dimethoxybenzaldehyde SCHEMBL29268876 0.80 ALDH1A1 (0.85) ALDH1A1TSHRHPGDTDP1AOX1
SCHEMBL12013081 0.80 ALDH5A1 (0.51) ALDH1A1HPGDALDH5A1ABATKMT2A
3,4-Dimethoxybenzaldehyde SCHEMBL5308959 0.79 ALDH1A1 (1.00) ALDH1A1TSHRHPGDTDP1AOX1
3,4-Dimethoxybenzaldehyde SCHEMBL25202 0.79 ALDH1A1 (1.00) ALDH1A1TSHRHPGDTDP1AOX1
3,4-Dimethoxybenzaldehyde SCHEMBL1330962 0.79 ALDH1A1 (1.00) ALDH1A1TSHRHPGDTDP1AOX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6407229-B1 ENZYME INHIBITOR SANOCHEMIA PHARMAZEUTIKA AG (AT) 2002-06-18 US disclosed
US-6369238-B1 ENZYME INHIBITORS USED IN THE TREATMENT OF ALZHEIMER'S DISEASE SANOCHEMIA PHARMAZEUTICA (AT) 2002-04-09 US disclosed
US-6043359-A REACTING A BENZALDEHYDE DERIVATIVE WITH A BENZENE ETHYLAMINE DERIVATIVE TO FORM A SCHIFF BASE, REDUCING THE SCHIFF BASE TO PRODUCE AN INTERMEDIATE, OXIDATIVELY CYCLYZATION, THEN STEREOSELECTIVE REDUCTION FORMS END PRODUCT SANOCHEMIA PHARMAZEUTICA AKTIENGESELLSCHAFT (AT) 2000-03-28 US disclosed
EP-0787115-B1 PROCESS FOR PRODUCING DERIVATIVES OF 4a,5,9,10,11,12,-HEXAHYDRO-6H-BENZOFURO[3a,3,2-ef][2]BENZAZEPINE SANOCHEMIA PHARMAZEUTIKA AG (AT) 2000-01-05 EP disclosed