Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 5/20 | 0.53 |
| ▸ | RXRA | P19793 | 1/20 | 0.51 |
| ▸ | RXRB | P28702 | 1/20 | 0.51 |
| ▸ | RXRG | P48443 | 1/20 | 0.51 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.50 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.49 |
| ▸ | TACR1 | P25103 | 2/20 | 0.49 |
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7713126 | 0.86 | SMN1; SMN2 (0.56) | KMT2ASMN1; SMN2MAOBRXRARXRB | |
| SCHEMBL3823697 | 0.83 | RXRA (0.69) | MAOBRXRARXRBRXRGCYP4F2 | |
| SCHEMBL12446273 | 0.82 | SMN1; SMN2 (0.63) | KMT2ASMN1; SMN2MAOBCYP4F2CYP4A11 | |
| SCHEMBL19415790 | 0.82 | SMN1; SMN2 (0.67) | KMT2ASMN1; SMN2MAOBCYP4F2CYP4A11 | |
| SCHEMBL5772666 | 0.82 | SMN1; SMN2 (0.67) | KMT2ASMN1; SMN2MAOBCYP4F2CYP4A11 | |
| SCHEMBL5772678 | 0.82 | SMN1; SMN2 (0.67) | KMT2ASMN1; SMN2MAOBCYP4F2CYP4A11 | |
| SCHEMBL2459328 | 0.80 | KMT2A (0.52) | KMT2ASMN1; SMN2MAOBRXRARXRB | |
| SCHEMBL6727908 | 0.80 | MAPK1 (0.56) | KMT2ASMN1; SMN2MAOBSGMS2 | |
| Hydrochloric Acid SCHEMBL2463286 | 0.79 | KMT2A (0.51) | KMT2ASMN1; SMN2MAOBCYP4F2CYP4A11 | |
| SCHEMBL2749197 | 0.79 | KMT2A (0.63) | KMT2ASMN1; SMN2MAOBCYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441017-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1214326-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001017992-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |
| WO-2001018006-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |