Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 3/20 | 0.34 |
| ▸ | MME | P08473 | 2/20 | 0.34 |
| ▸ | XIAP | P98170 | 4/20 | 0.33 |
| ▸ | BIRC3 | Q13489 | 4/20 | 0.33 |
| ▸ | BIRC2 | Q13490 | 4/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14170111 | 0.73 | BRD4 (0.38) | ADRA2AADRA2BADRA2CSLC6A2HTR2A | |
| SCHEMBL12747426 | 0.73 | ACE (0.50) | ADRA2AADRA2BADRA2CSLC6A2HTR2A | |
| SCHEMBL14170247 | 0.71 | XIAP (0.38) | ADRA2AADRA2BADRA2CSLC6A2HTR2A | |
| SCHEMBL14169932 | 0.71 | ADRA2A (0.43) | ADRA2AADRA2BADRA2CSLC6A2HTR2A | |
| SCHEMBL14169897 | 0.70 | OPRM1 (0.40) | PDPK1PRCPXIAPBIRC3BIRC2 | |
| SCHEMBL14170126 | 0.69 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CSLC6A2HTR2A | |
| SCHEMBL12747479 | 0.68 | ACE (0.40) | ADRA2AADRA2BADRA2CSLC6A2HTR2A | |
| SCHEMBL14392106 | 0.67 | PRCP (0.38) | HTR2AHTR2CHTR2BPRCPOPRM1 | |
| SCHEMBL10060256 | 0.67 | PRCP (0.38) | HTR2AHTR2CHTR2BPRCPOPRM1 | |
| SCHEMBL14170136 | 0.66 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CSLC6A2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6509330-B2 | Angiotensin converting enzyme (ACE); neutral endopeptidase (NEP); containing a dipeptide derived from an amino acid, or a conformationally restricted dipeptide mimic | BRISTOL-MYERS SQUIBB COMPANY | 2003-01-21 | — | — | US | disclosed |