Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.36 |
| ▸ | CCNC | P24863 | 3/20 | 0.36 |
| ▸ | CDK8 | P49336 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5207386 | 0.87 | STK17A (0.42) | STK17AKCNH2SCN9ASCN5ACCNC | |
| SCHEMBL7163367 | 0.86 | RAB9A (0.42) | STK17AKCNH2SCN9ASCN5AMAPT | |
| SCHEMBL1375420 | 0.84 | KCNH2 (0.38) | STK17AKCNH2SCN9ASCN5ACCNC | |
| Hydrochloric Acid SCHEMBL5205951 | 0.84 | KCNH2 (0.40) | STK17AKCNH2SCN9ASCN5ACCNC | |
| SCHEMBL5205013 | 0.83 | KCNH2 (0.40) | STK17AKCNH2SCN9ASCN5ACCNC | |
| SCHEMBL7708449 | 0.83 | NPC1 (0.45) | STK17AKCNH2SCN9ASCN5ACCNC | |
| SCHEMBL5204141 | 0.82 | KCNH2 (0.36) | STK17AKCNH2SCN9ASCN5ACCNC | |
| Hydrochloric Acid SCHEMBL7714006 | 0.82 | KDM4E (0.44) | STK17AKCNH2SCN9ASCN5ACCNC | |
| SCHEMBL1375549 | 0.82 | STK17A (0.46) | STK17AKCNH2SCN9ASCN5AMAPT | |
| SCHEMBL1376217 | 0.81 | NUDT1 (0.43) | STK17AKCNH2SCN9ASCN5ACCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6440965-B1 | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system | KRENITSKY PHARMACEUTICALS, INC. | 2002-08-27 | — | — | US | disclosed |