Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 12/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7708416 | 0.87 | HRH4 (0.55) | HRH4HTR1ADRD2 | |
| SCHEMBL7716722 | 0.85 | HRH4 (0.51) | HRH4NPC1GAARAB9AHTR3A | |
| SCHEMBL7714260 | 0.85 | HRH4 (0.51) | HRH4SMN1; SMN2NPC1GAARAB9A | |
| SCHEMBL7714501 | 0.84 | LMNA (0.46) | HRH4SMN1; SMN2GAARAB9AHTR1A | |
| SCHEMBL7714712 | 0.82 | KMT2A (0.54) | HRH4HTR3A | |
| SCHEMBL7708460 | 0.82 | KMT2A (0.54) | HRH4HTR3A | |
| SCHEMBL7716613 | 0.82 | HRH4 (0.52) | HRH4SMN1; SMN2NPC1GAARAB9A | |
| SCHEMBL7714490 | 0.81 | ALK (0.53) | HRH4 | |
| SCHEMBL7716737 | 0.80 | ALDH1A1 (0.48) | HRH4SMN1; SMN2GAARAB9AHTR3A | |
| SCHEMBL7714132 | 0.79 | HRH4 (0.53) | HRH4HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6440965-B1 | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system | KRENITSKY PHARMACEUTICALS, INC. | 2002-08-27 | — | — | US | disclosed |