Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7714244 | 1.00 | ACP1 (0.36) | ACP1TP53MAPTMEN1HPGD | |
| SCHEMBL7105529 | 0.84 | KMT2A (0.34) | TP53MAPTMEN1KMT2ATDP1 | |
| SCHEMBL7714235 | 0.81 | MAPT (0.36) | ACP1TP53MAPTMEN1HPGD | |
| SCHEMBL7258656 | 0.81 | ELANE (0.38) | TP53MAPTMEN1HPGDKMT2A | |
| SCHEMBL7258056 | 0.78 | ITGB1 (0.43) | ADORA3 | |
| SCHEMBL7258050 | 0.78 | ITGB1 (0.43) | ADORA3 | |
| SCHEMBL7716185 | 0.77 | TP53 (0.33) | ACP1TP53MAPTMEN1KMT2A | |
| SCHEMBL7716183 | 0.76 | MAPT (0.37) | TP53MAPTMEN1HPGDKMT2A | |
| SCHEMBL7105250 | 0.73 | EGFR (0.40) | TP53MAPTHPGDKMT2AKDM4E | |
| SCHEMBL7260154 | 0.72 | RAB9A (0.35) | TP53MAPTKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6469025-B1 | FOR THE PROPHYLAXIS OR TREATMENT OF A DISEASE OR DISORDER IN A MAMMAL IN WHICH THE EXTRAVASATION OF LEUKOCYTES PLAYS A ROLE; INHIBITING THE BINDING OF ALPHA 4 INTEGRINS TO THEIR LIGANDS | CELLTECH R&D LTD. (GB) | 2002-10-22 | — | — | US | disclosed |