SCHEMBL7714458

SCHEMBL7714458

COc1ccc(CNCCc2ccc(O)cc2)cc1OC(=O)C(C)(C)C

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCHE P06276 2/20 0.61
HTT P42858 3/20 0.55
CYP2D6 P10635 2/20 0.55
CYP2C19 P33261 2/20 0.55
CYP3A4 P08684 2/20 0.55
CYP2C9 P11712 1/20 0.55
CA12 O43570 1/20 0.53
CA1 P00915 1/20 0.53
CA2 P00918 1/20 0.53
CA4 P22748 1/20 0.53
CA9 Q16790 1/20 0.53
ALDH1A1 P00352 4/20 0.52
KDM4E B2RXH2 4/20 0.51
GLA P06280 1/20 0.51
SLC2A1 P11166 1/20 0.51
TDP1 Q9NUW8 1/20 0.51
LMNA P02545 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
NPSR1 Q6W5P4 1/20 0.49
SLC22A1 O15245 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5069115 0.85 BCHE (0.76) BCHEHTTCYP2D6CYP2C19CYP3A4
SCHEMBL1719403 0.79 BCHE (0.67) BCHEHTTCYP2D6CYP2C19CYP3A4
SCHEMBL30213077 0.79 BCHE (0.67) BCHEHTTCYP2D6CYP2C19CYP3A4
SCHEMBL7716811 0.78 L3MBTL1 (0.44) BCHECYP2D6CYP2C19CYP3A4CYP2C9
SCHEMBL9404939 0.76 ADRB2 (0.49) CYP2D6CYP2C19CYP3A4CA12CA1
SCHEMBL19532590 0.76 BCHE (0.71) BCHEHTTCYP2D6CYP2C19CYP3A4
SCHEMBL19532591 0.76 BCHE (1.00) BCHEHTTCYP2D6CYP2C19CYP3A4
Acetic Acid SCHEMBL28722943 0.75 HTT (0.76) BCHEHTTCYP2D6CYP2C19CYP3A4
SCHEMBL9404905 0.75 ADRB2 (0.48) CYP3A4CA12CA1CA2CA9
SCHEMBL19532621 0.74 BCHE (1.00) BCHEHTTCYP2D6CYP2C19CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6407229-B1 ENZYME INHIBITOR SANOCHEMIA PHARMAZEUTIKA AG (AT) 2002-06-18 US disclosed
US-6369238-B1 ENZYME INHIBITORS USED IN THE TREATMENT OF ALZHEIMER'S DISEASE SANOCHEMIA PHARMAZEUTICA (AT) 2002-04-09 US disclosed
US-6043359-A REACTING A BENZALDEHYDE DERIVATIVE WITH A BENZENE ETHYLAMINE DERIVATIVE TO FORM A SCHIFF BASE, REDUCING THE SCHIFF BASE TO PRODUCE AN INTERMEDIATE, OXIDATIVELY CYCLYZATION, THEN STEREOSELECTIVE REDUCTION FORMS END PRODUCT SANOCHEMIA PHARMAZEUTICA AKTIENGESELLSCHAFT (AT) 2000-03-28 US disclosed
EP-0787115-B1 PROCESS FOR PRODUCING DERIVATIVES OF 4a,5,9,10,11,12,-HEXAHYDRO-6H-BENZOFURO[3a,3,2-ef][2]BENZAZEPINE SANOCHEMIA PHARMAZEUTIKA AG (AT) 2000-01-05 EP disclosed
EP-0787115-A1 PROCESS FOR PRODUCING DERIVATIVES OF 4a,5,9,10,11,12,-HEXAHYDRO-6H-BENZOFURO 3a,3,2-ef] 2]BENZAZEPINE Waldheim Pharmazeutika Gesellschaft m.b.H. (AT) 1997-08-06 EP disclosed
WO-1996012692-A1 PROCESS FOR PRODUCING DERIVATIVES OF 4a,5,9,10,11,12,-HEXAHYDRO-6H-BENZOFURO[3a,3,2-ef][2]BENZAZEPINE WALDHEIM PHARMAZEUTIKA GESELLSCHAFT M.B.H. (AT) 1996-05-02 WO disclosed