Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 8/20 | 0.50 |
| ▸ | RARB | P10826 | 8/20 | 0.50 |
| ▸ | RARG | P13631 | 8/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.50 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.50 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.50 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.46 |
| ▸ | RXRA | P19793 | 7/20 | 0.44 |
| ▸ | RXRB | P28702 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 5/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7714832 | 0.84 | RARB (0.51) | RARARARBRARGCYP3A4CYP26A1 | |
| SCHEMBL7713134 | 0.82 | RARB (0.74) | RARARARBRARGCYP3A4CYP26A1 | |
| SCHEMBL8839101 | 0.79 | RXRA (0.48) | RARARARBRARGCYP3A4CYP26A1 | |
| SCHEMBL7715161 | 0.78 | CYP3A4 (0.54) | RARARARBRARGCYP3A4CYP26A1 | |
| SCHEMBL8106548 | 0.78 | CYP3A4 (0.47) | RARARARBRARGCYP3A4CYP26A1 | |
| SCHEMBL8839100 | 0.78 | RXRA (0.45) | RARARARBRARGCYP3A4CYP26A1 | |
| SCHEMBL6378967 | 0.77 | RARB (0.68) | RARARARBRARGCYP3A4CYP26A1 | |
| SCHEMBL8839136 | 0.77 | RARB (0.52) | RARARARBRARGCYP3A4CYP26A1 | |
| SCHEMBL8839222 | 0.76 | RXRA (0.50) | RARARARBRARGCYP3A4CYP26A1 | |
| SCHEMBL8102732 | 0.74 | RXRA (0.42) | RARARARBRARGCYP3A4CYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6368608-B1 | SKIN DISORDERS | CENTRE INTERNATIONAL DE RECHERCHE DERMATOLOGIQUES GALDERMA (C.I.R.D.) (FR) | 2002-04-09 | — | — | US | disclosed |
| US-6162445-A | Polyaromatic propynyl compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-12-19 | — | — | US | disclosed |
| US-5716624-A | USEFUL FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, OPTHALMOLOGICAL DISORDERS, AS WELL AS MAMMALIAN SKIN AND HAIR CONDITIONS/DISORDERS | C.I.R.D. GALDERMA (FR) | 1998-02-10 | — | — | US | disclosed |