Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 11/20 | 0.74 |
| ▸ | RARG | P13631 | 11/20 | 0.74 |
| ▸ | RARA | P10276 | 8/20 | 0.74 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.74 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.74 |
| ▸ | RXRA | P19793 | 11/20 | 0.64 |
| ▸ | RXRB | P28702 | 9/20 | 0.61 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.59 |
| ▸ | RXRG | P48443 | 6/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6378967 | 0.94 | RARB (0.68) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL3302926 | 0.85 | RARB (1.00) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL29353973 | 0.85 | RARB (1.00) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7713109 | 0.84 | CYP3A4 (0.66) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL6260318 | 0.82 | RARB (0.50) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL1991598 | 0.82 | RARB (0.50) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL6159273 | 0.82 | RARB (0.50) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7717546 | 0.82 | RXRA (0.60) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7714816 | 0.82 | RARA (0.50) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7709226 | 0.82 | RARG (0.49) | RARBRARGRARACYP26A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6162445-A | Polyaromatic propynyl compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-12-19 | — | — | US | claimed |
| US-6001885-A | INHIBITING VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) EXPRESSION IN KERATINOCYTES BY ADMINISTERING AT LEAST ONE RETINOID; USEFUL FOR TREATING DISEASES RELATING TO VEGF OVEREXPRESSION, SUCH AS PSORIASIS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) | 1999-12-14 | — | — | US | claimed |
| EP-0661258-B1 | Biaromatic propynyl compounds, pharmaceutical compositions and cosmetics containing them and their uses | CIRD GALDERMA (FR) | 1998-04-08 | — | — | EP | claimed |
| EP-4623922-A2 | ALTERING MICROBIAL POPULATIONS & MODIFYING MICROBIOTA | SNIPR Technologies Limited (GB) | 2025-10-01 | — | — | EP | disclosed |
| US-6368608-B1 | SKIN DISORDERS | CENTRE INTERNATIONAL DE RECHERCHE DERMATOLOGIQUES GALDERMA (C.I.R.D.) (FR) | 2002-04-09 | — | — | US | disclosed |
| US-6313162-B1 | FOR USE IN HUMAN OR VETERINARY MEDICINE SUCH AS DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR AND OPHHALMOLOGICAL DISORDERS; AND IN COSMETICS | CENTRE INTERNATIONAL DE RECHERCHE DERMATOLOGIQUES GALDERMA (C.I.R.D.) GALDERMA (FR) | 2001-11-06 | — | — | US | disclosed |
| US-6162445-A | Polyaromatic propynyl compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-12-19 | — | — | US | disclosed |
| US-6046220-A | ADMINISTERING TO THE PATIENT A PROPYNYL OR DIENYL BIAROMATIC COMPOUND TO TREAT A SKIN DISORDER, INFLAMMATORY CONDITIONS, VISION DEFECTS, ALOPECIA, CARDIOVASCULAR DISORDER, CANCER OR PRECANCER AND INSULIN DEPENDANT DIABETES | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-04-04 | — | — | US | disclosed |
| US-6001885-A | INHIBITING VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) EXPRESSION IN KERATINOCYTES BY ADMINISTERING AT LEAST ONE RETINOID; USEFUL FOR TREATING DISEASES RELATING TO VEGF OVEREXPRESSION, SUCH AS PSORIASIS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) | 1999-12-14 | — | — | US | disclosed |
| EP-0661258-B1 | Biaromatic propynyl compounds, pharmaceutical compositions and cosmetics containing them and their uses | CIRD GALDERMA (FR) | 1998-04-08 | — | — | EP | disclosed |
| US-5716624-A | USEFUL FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, OPTHALMOLOGICAL DISORDERS, AS WELL AS MAMMALIAN SKIN AND HAIR CONDITIONS/DISORDERS | C.I.R.D. GALDERMA (FR) | 1998-02-10 | — | — | US | disclosed |
| EP-0661258-A1 | Biaromatic propynyl compounds, pharmaceutical compositions and cosmetics containing them and their uses | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA) (FR) | 1995-07-05 | — | — | EP | disclosed |