SCHEMBL7714873

SCHEMBL7714873

COC(=O)C(C(=O)O)c1ccc(N)c(C(F)(F)F)c1

nearest known ligand 0.41

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 12/20 0.41
AKR1C2 P52895 12/20 0.41
AR P10275 1/20 0.40
AKR1C4 P17516 2/20 0.39
AKR1C1 Q04828 2/20 0.39
AKR1B10 O60218 1/20 0.39
FFAR4 Q5NUL3 4/20 0.39
CFTR P13569 2/20 0.39
MAPK1 P28482 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2745486 0.82 AR (0.40) AKR1C3AKR1C2ARAKR1C4AKR1C1
SCHEMBL3711505 0.81 HDAC1 (0.41) AKR1C3AKR1C2AKR1C4AKR1C1
SCHEMBL11270744 0.78 AKR1C3 (0.59) AKR1C3AKR1C2AKR1C4AKR1C1
SCHEMBL7934481 0.76 AKR1C3 (0.47) AKR1C3AKR1C2MAPK1
SCHEMBL9300518 0.74 ALDH1A1 (0.47)
Cadaverine Tartrate SCHEMBL3165443 0.71 ADRB2 (0.55) AKR1C3AKR1C2AR
SCHEMBL3653822 0.71 AKR1C3 (0.44) AKR1C3AKR1C2ARAKR1C4AKR1C1
SCHEMBL17665552 0.70 MEN1 (0.39) AKR1C3AKR1C2AKR1C4AKR1C1AKR1B10
SCHEMBL30868019 0.70 GAA (0.47) AKR1C3AKR1C2ARFFAR4
SCHEMBL397079 0.70 GAA (0.47) AKR1C3AKR1C2ARFFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0865421-B1 ARYLETHANOLAMINE DERIVATIVES AND THEIR USE AS AGONISTS OF ATYPICAL BETA-ADRENOCEPTORS GLAXO GROUP LTD (GB) 2002-03-27 EP disclosed
US-6048872-A DIETETICS; ANTIDIABETIC AGENTS; CARDIOVASCULAR DISORDERS; GASTROINTESTINAL DISORDERS GLAXO WELLCOME INC. (US) 2000-04-11 US disclosed
EP-0865421-A1 ARYLETHANOLAMINE DERIVATIVES AND THEIR USE AS AGONISTS OF ATYPICAL BETA-ADRENOCEPTORS GLAXO GROUP LIMITED (GB) 1998-09-23 EP disclosed
WO-1997021665-A1 ARYLETHANOLAMINE DERIVATIVES AND THEIR USE AS AGONISTS OF ATYPICAL BETA-ADRENOCEPTORS GLAXO GROUP LIMITED (GB) 1997-06-19 WO disclosed