Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.59 |
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 4/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | LIPE | Q05469 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL292275 | 0.88 | APP (0.72) | APPLTA4HMAPK14MAPTL3MBTL1 | |
| SCHEMBL5538708 | 0.88 | MAPT (0.63) | APPLTA4HMAPK14MAPTL3MBTL1 | |
| Hydrochloric Acid SCHEMBL584918 | 0.86 | APP (0.70) | APPLTA4HMAPK14MAPTL3MBTL1 | |
| Aniline SCHEMBL22169167 | 0.83 | APP (0.66) | APPLTA4HMAPK14MAPTL3MBTL1 | |
| SCHEMBL8586421 | 0.82 | MAOB (0.62) | APPLTA4HMAPTL3MBTL1MAOB | |
| SCHEMBL339812 | 0.82 | MAPT (0.71) | APPLTA4HMAPK14MAPTL3MBTL1 | |
| SCHEMBL1361220 | 0.79 | KDM4E (0.62) | APPLTA4HMAPTL3MBTL1TDP1 | |
| SCHEMBL6289306 | 0.79 | KDM4E (0.62) | APPLTA4HMAPTL3MBTL1TDP1 | |
| SCHEMBL6293125 | 0.79 | KDM4E (0.62) | APPLTA4HMAPTL3MBTL1TDP1 | |
| SCHEMBL6293884 | 0.79 | KDM4E (0.62) | APPLTA4HMAPTL3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-10245336-A | — | — | None | — | — | JP | disclosed |
| US-6441017-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1214326-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001051125-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-07-19 | — | — | WO | disclosed |
| WO-2001018006-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |
| JP-H10245336-A | INHIBITOR TO NA/CA-EXCHANGE SYSTEM | TAISHO PHARMACEUT CO LTD | 1998-09-14 | — | — | JP | disclosed |