Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.47 |
| ▸ | CYSLTR2 | Q9NS75 | 7/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6089752 | 0.94 | CYSLTR1 (0.55) | CYSLTR1CYSLTR2PDE10A | |
| SCHEMBL10544006 | 0.94 | CYSLTR1 (0.51) | CYSLTR1CYSLTR2PDE10A | |
| SCHEMBL10546151 | 0.92 | CYSLTR1 (0.45) | CYSLTR1CYSLTR2PDE10A | |
| SCHEMBL7008540 | 0.92 | CYSLTR1 (0.55) | CYSLTR1CYSLTR2 | |
| SCHEMBL10547968 | 0.88 | CYSLTR1 (0.46) | CYSLTR1CYSLTR2PDE10A | |
| SCHEMBL7710959 | 0.86 | CYSLTR1 (0.56) | CYSLTR1CYSLTR2 | |
| SCHEMBL10421916 | 0.86 | CYSLTR1 (0.56) | CYSLTR1CYSLTR2 | |
| SCHEMBL7717000 | 0.85 | CYSLTR1 (0.55) | CYSLTR1CYSLTR2 | |
| SCHEMBL10546763 | 0.84 | CYSLTR1 (0.62) | CYSLTR1CYSLTR2PDE10A | |
| SCHEMBL10422016 | 0.84 | CYSLTR1 (0.53) | CYSLTR1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376512-B1 | FOR TREATING PHYSIOLOGICAL CONDITION IN PATIENT WHEREIN SAID CONDITION IS ASSOCIATED WITH A PHYSIOLOGICALLY DETRIMENTAL LEVELS OF INSULIN, GLUCOSE, FREE FATTY ACIDS, OR TRIGLYCERIDES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-04-23 | — | — | US | disclosed |
| US-5059610-A | QUINOLINE DERIVATIVES AND THEIR USE AS ANTAGONISTS OF LEUKOTRIENE D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-10-22 | — | — | US | disclosed |
| US-4920132-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |