Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 10/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 10/20 | 0.37 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7710613 | 0.89 | CYP11B1 (0.38) | MKNK1MKNK2BACE1ERN1PIM1 | |
| SCHEMBL7712670 | 0.87 | ERN1 (0.34) | MKNK1MKNK2BACE1ERN1CYP11B2 | |
| SCHEMBL7711100 | 0.87 | KDR (0.39) | CYP11B1CYP11B2KCNH2 | |
| SCHEMBL7710842 | 0.85 | BACE1 (0.33) | BACE1KCNH2MEN1 | |
| SCHEMBL7710882 | 0.83 | CCNC (0.38) | BACE1CYP11B1CYP11B2LMNACYP1A2 | |
| SCHEMBL7712995 | 0.78 | BACE1 (0.41) | BACE1CYP11B1CYP11B2KCNH2CYP1A2 | |
| SCHEMBL7705214 | 0.71 | TYR (0.30) | — | |
| SCHEMBL7710836 | 0.70 | ERN1 (0.35) | ERN1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18159648 | 0.61 | CYP11B1 (0.55) | MKNK1MKNK2BACE1PIM1PIM2 | |
| SCHEMBL5094873 | 0.61 | CYP1A2 (0.43) | MKNK1MKNK2CYP11B1CYP11B2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130741-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-20 | — | — | WO | disclosed |