Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 2/20 | 0.38 |
| ▸ | CDK8 | P49336 | 2/20 | 0.38 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.33 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7712995 | 0.84 | BACE1 (0.41) | CYP11B1CYP11B2CYP1A2CYP3A4CTSD | |
| SCHEMBL7715200 | 0.83 | MKNK1 (0.37) | CYP11B1CYP11B2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7710836 | 0.81 | ERN1 (0.35) | NPC1RAB9AHPGDHSD17B1CYP1A2 | |
| SCHEMBL7711100 | 0.79 | KDR (0.39) | CYP11B1CYP11B2MAPT | |
| SCHEMBL7708344 | 0.79 | ERN1 (0.32) | BACE1 | |
| SCHEMBL7705409 | 0.79 | BACE1 (0.45) | CTSDBACE1DHODH | |
| SCHEMBL7710613 | 0.78 | CYP11B1 (0.38) | CYP11B1CYP11B2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7711197 | 0.76 | MKNK1 (0.37) | CYP11B1CYP11B2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL7712670 | 0.73 | ERN1 (0.34) | CYP11B2BACE1 | |
| SCHEMBL7705408 | 0.70 | BACE1 (0.35) | CTSDBACE1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130741-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-20 | — | — | WO | disclosed |