SCHEMBL7715274

SCHEMBL7715274

CN1CCCC2(CCNCC2)C1=O

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 5/20 0.38
GRIN1 Q05586 2/20 0.37
GRIN2A Q12879 2/20 0.37
LTA4H P09960 1/20 0.36
BRD4 O60885 1/20 0.34
BRD2 P25440 1/20 0.34
CRBN Q96SW2 2/20 0.32
PDE4A P27815 1/20 0.31
PDE4B Q07343 1/20 0.31
PDE4C Q08493 1/20 0.31
PDE4D Q08499 1/20 0.31
HTR7 P34969 1/20 0.30
USP2 O75604 1/20 0.30
ALDH1A1 P00352 1/20 0.30
CYP3A4 P08684 1/20 0.30
CYP2D6 P10635 1/20 0.30
TSHR P16473 1/20 0.30
CYP2C19 P33261 1/20 0.30
CYP1A2 P05177 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL345569 0.88 LTA4H (0.34) HRH3GRIN1GRIN2ALTA4HCRBN
Hydrochloric Acid SCHEMBL2637438 0.86 LTA4H (0.33) HRH3GRIN1GRIN2ALTA4HCRBN
SCHEMBL16190002 0.86 GRIN1 (0.42) GRIN1GRIN2ALTA4HBRD4BRD2
Hydrochloric Acid SCHEMBL2637436 0.85 OTUD7B (0.34) HRH3GRIN1GRIN2ALTA4HCRBN
Hydrochloric Acid SCHEMBL2635368 0.80 GRIN1 (0.35) GRIN1GRIN2ALTA4HBRD4BRD2
SCHEMBL10186804 0.80 CHRM2 (0.44) GRIN1GRIN2ALTA4HBRD4BRD2
SCHEMBL1753723 0.79 NEK2 (0.38) CRBNPDE4APDE4BPDE4CPDE4D
Hydrochloric Acid SCHEMBL2635366 0.79 GRIN1 (0.34) GRIN1GRIN2ALTA4HBRD4BRD2
SCHEMBL25738952 0.77 GRIN1 (0.40) GRIN1GRIN2ALTA4HBRD4BRD2
SCHEMBL13460109 0.77 GRIN1 (0.40) HRH3GRIN1GRIN2ALTA4HBRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3630749-B9 2-QUINOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECH LTD (GB) 2024-05-29 EP disclosed
EP-4371562-A2 2-QUINOLONE DERIVED INHIBITORS OF BCL6 Cancer Research Technology Limited (GB) 2024-05-22 EP disclosed
EP-3630749-B1 2-QUINOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECH LTD (GB) 2024-01-10 EP disclosed
US-11512095-B2 BCL6 inhibitors THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) 2022-11-29 US disclosed
US-11161839-B2 2-quinolone derived inhibitors of BCL6 THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) 2021-11-02 US disclosed
US-11161839-B2 2-quinolone derived inhibitors of BCL6 THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) 2021-11-02 US disclosed
US-20210206756-A1 2-QUINOLONE DERIVED INHIBITORS OF BCL6 THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) 2021-07-08 US disclosed
US-20210206756-A1 2-QUINOLONE DERIVED INHIBITORS OF BCL6 THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) 2021-07-08 US disclosed
US-20210163497-A1 BCL6 INHIBITORS THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) 2021-06-03 US disclosed
EP-3630749-A1 2-QUINOLONE DERIVED INHIBITORS OF BCL6 Cancer Research Technology Limited (GB) 2020-04-08 EP disclosed
WO-2018215798-A1 2-QUINOLONE DERIVED INHIBITORS OF BCL6 CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2018-11-29 WO disclosed
US-9828373-B2 2-amino-pyrido[2,3-D]pyrimidin-7(8H)-one derivatives as CDK inhibitors and uses thereof SUNSHINE LAKE PHARMA CO., LTD. (CN) 2017-11-28 US disclosed
US-9662339-B2 Benzodioxane inhibitors of leukotriene production for combination therapy BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2017-05-30 US disclosed
EP-2822941-B1 BENZODIOXANES IN COMBINATION WITH STATINS FOR INHIBITING LEUKOTRIENE PRODUCTION BOEHRINGER INGELHEIM INT (DE) 2017-05-10 EP disclosed
US-20170121323-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE DERIVATIVES AS CDK INHIBITORS AND USES THEREOF SUNSHINE LAKE PHARMA CO., LTD. (CN) 2017-05-04 US disclosed
EP-2536730-B1 PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF CDK4/6 NOVARTIS AG (CH) 2015-07-08 EP disclosed
EP-2822941-A1 BENZODIOXANES IN COMBINATION WITH OTHER ACTIVES FOR INHIBITING LEUKOTRIENE PRODUCTION Boehringer Ingelheim International GmbH (DE) 2015-01-14 EP disclosed
WO-2013131901-A1 BENZODIOXANES IN COMBINATION WITH OTHER ACTIVES FOR INHIBITING LEUKOTRIENE PRODUCTION BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-09-12 WO disclosed
WO-2011130232-A1 COMBINATION COMPRISING A CYCLIN DEPENDENT KINASE 4 OR CYCLIN DEPENDENT KINASE (CDK4/6) INHIBITOR AND AN MTOR INHIBITOR FOR TREATING CANCER NOVARTIS AG (CH) 2011-10-20 WO disclosed
WO-2011101409-A1 PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF CDK4/6 NOVARTIS AG (CH) 2011-08-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210163497-A1 BCL6 INHIBITORS BCL6, BCL6B, BCL3 HRH3 1816/4885GRIN1 3998/4885GRIN2A 4793/4885
US-20170121323-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE DERIVATIVES AS CDK INHIBITORS AND USES THEREOF CDK6, CDK4, CDK7 HRH3 1984/4885GRIN1 2975/4885GRIN2A 2752/4885
US-11161839-B2 2-quinolone derived inhibitors of BCL6 BCL6, BCL6B, BCL3 HRH3 1719/4885GRIN1 4233/4885GRIN2A 4558/4885
US-11512095-B2 BCL6 inhibitors BCL6, BCL6B, BCL3 HRH3 1816/4885GRIN1 3998/4885GRIN2A 4793/4885
US-20210206756-A1 2-QUINOLONE DERIVED INHIBITORS OF BCL6 BCL6, BCL6B, BCL3 HRH3 1719/4885GRIN1 4233/4885GRIN2A 4558/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.