Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 5/20 | 0.51 |
| ▸ | CA2 | P00918 | 5/20 | 0.51 |
| ▸ | CA9 | Q16790 | 3/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | LAP3 | P28838 | 1/20 | 0.44 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27887665 | 0.86 | CA1 (0.53) | CA1CA2CA9CA12IDO1 | |
| SCHEMBL4161005 | 0.83 | IDO1 (0.53) | IDO1ALDH1A1SLC1A3SLC1A1TDP1 | |
| SCHEMBL10441465 | 0.83 | IDO1 (0.53) | IDO1ALDH1A1SLC1A3SLC1A1TDP1 | |
| SCHEMBL1245400 | 0.82 | ALDH1A1 (0.50) | IDO1ALDH1A1SLC1A3SLC1A1TDP1 | |
| SCHEMBL3471267 | 0.82 | SLC1A1 (0.55) | IDO1ALDH1A1SLC1A3SLC1A1TDP1 | |
| SCHEMBL5019164 | 0.82 | ALDH1A1 (0.50) | IDO1ALDH1A1SLC1A3SLC1A1TDP1 | |
| SCHEMBL535584 | 0.82 | ALDH1A1 (0.50) | IDO1ALDH1A1SLC1A3SLC1A1TDP1 | |
| SCHEMBL22433276 | 0.82 | ALDH1A1 (0.50) | IDO1ALDH1A1SLC1A3SLC1A1TDP1 | |
| SCHEMBL22433275 | 0.82 | ALDH1A1 (0.50) | IDO1ALDH1A1SLC1A3SLC1A1TDP1 | |
| SCHEMBL5618771 | 0.82 | SLC1A1 (0.55) | IDO1ALDH1A1SLC1A3SLC1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436691-B1 | CONJUGATE WHICH IS SUBSTANTIALLY NON-IMMUNOGENIC IN HUMANS COMPRISING TARGETING MOIETY CAPABLE OF BINDING WITH TUMOR ASSOCIATED ANTIGEN LINKED TO MUTATED FORM OF CARBOXYPEPTIDASE B ENZYME CAPABLE OF CONVERTING PRODRUG INTO ANTICANCER DRUG | ZENECA LIMITED (GB) | 2002-08-20 | — | — | US | disclosed |
| EP-0844885-A2 | CHEMICAL COMPOUNDS | ZENECA LIMITED (GB) | 1998-06-03 | — | — | EP | disclosed |
| WO-1997007769-A2 | CHEMICAL COMPOUNDS | ZENECA LIMITED (GB) | 1997-03-06 | — | — | WO | disclosed |