Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.52 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.52 |
| ▸ | PRKCG | P05129 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | ROS1 | P08922 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7715851 | 0.90 | SMN1; SMN2 (0.67) | SMN1; SMN2DUSP3NPC1RAB9APTPN7 | |
| SCHEMBL7715505 | 0.88 | DUSP3 (0.65) | SMN1; SMN2DUSP3KMT2APTPN7 | |
| SCHEMBL29535608 | 0.86 | PTPN7 (0.64) | SMN1; SMN2DUSP3PTPN7 | |
| SCHEMBL898500 | 0.86 | PTPN7 (0.64) | SMN1; SMN2DUSP3PTPN7 | |
| SCHEMBL5065598 | 0.86 | NR1H4 (0.64) | SMN1; SMN2DUSP3PTPN7LMNA | |
| SCHEMBL5681720 | 0.83 | ERCC1 (0.69) | SMN1; SMN2DUSP3PTPN7 | |
| SCHEMBL5065591 | 0.82 | NR1H4 (0.60) | SMN1; SMN2KMT2ALMNA | |
| SCHEMBL14082977 | 0.81 | SMN1; SMN2 (0.58) | SMN1; SMN2KMT2AGSK3AGSK3BPRKX | |
| SCHEMBL9416663 | 0.80 | NR1H4 (0.64) | SMN1; SMN2DUSP3KMT2APTPN7LMNA | |
| SCHEMBL6101468 | 0.80 | ALDH1A1 (0.65) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376524-B1 | ANTIALLERGENS, ANTIHISTAMINES | SUNESIS PHARMACEUTICALS, INC. | 2002-04-23 | — | — | US | disclosed |
| WO-2001098245-A2 | TRIPHENYL COMPOUNDS AS INTERLEUKIN-4 ANTAGONISTS | SUNESIS PHARMACEUTICALS, INC. (US) | 2001-12-27 | — | — | WO | disclosed |