Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29713612 | 0.91 | TSHR (0.55) | TSHRALOX15BRCA1ROCK1ALDH1A1 | |
| SCHEMBL930442 | 0.91 | TSHR (0.55) | TSHRALOX15BRCA1ROCK1ALDH1A1 | |
| SCHEMBL27946461 | 0.82 | ALDH1A1 (0.43) | TSHRALOX15BRCA1ROCK1ALDH1A1 | |
| SCHEMBL9462932 | 0.79 | AOC3 (0.41) | TSHRALDH1A1HPGDMAPTKDM4E | |
| 2-Methylindole SCHEMBL28819401 | 0.79 | NUDT1 (0.41) | TSHRALOX15BRCA1ROCK1ALDH1A1 | |
| Trifluoromethanesulfonic Acid SCHEMBL21408184 | 0.79 | TSHR (0.46) | TSHRALOX15BRCA1ALDH1A1HPGD | |
| Trifluoromethanesulfonic Acid SCHEMBL30159123 | 0.79 | TSHR (0.46) | TSHRALOX15BRCA1ALDH1A1HPGD | |
| SCHEMBL7384299 | 0.78 | TSHR (0.43) | TSHRALOX15BRCA1ROCK1ALDH1A1 | |
| SCHEMBL28670716 | 0.77 | AOC3 (0.39) | HPGDMAPTKMT2AMEN1KDM4E | |
| SCHEMBL16114138 | 0.72 | ROCK1 (0.46) | TSHRALOX15BRCA1ROCK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376670-B1 | BACTERICIDE FOR GRAMPOSITIVE BACTERIA | SEPRACOR INC. | 2002-04-23 | — | — | US | disclosed |
| US-6103905-A | EFFECTIVE AGAINST DRUG RESISTANT GRAMPOSITIVE BACTERIAL INFECTIONS; ANTIBIOTICS | SEPRACOR, INC. (US) | 2000-08-15 | — | — | US | disclosed |
| WO-2000034265-A2 | QUINOLINE-INDOLE ANTIMICROBIAL AGENTS | SEPRACOR, INC. (US) | 2000-06-15 | — | — | WO | disclosed |