Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 12/20 | 0.38 |
| ▸ | P2RX2 | Q9UBL9 | 12/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.35 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7716783 | 0.85 | CHRM4 (0.45) | FFAR4MTORRPTORMLST8 | |
| SCHEMBL7715960 | 0.82 | CHRM4 (0.46) | P2RX3P2RX2MAPTMEN1KMT2A | |
| SCHEMBL7714987 | 0.82 | KDM4E (0.44) | — | |
| SCHEMBL7715921 | 0.79 | FFAR4 (0.40) | FFAR4 | |
| SCHEMBL16404655 | 0.77 | MEN1 (0.52) | FFAR4GAAMAPTHSD17B10MEN1 | |
| SCHEMBL20319361 | 0.76 | ALDH1A1 (0.48) | FFAR4P2RX3P2RX2GAAMAPT | |
| SCHEMBL17708361 | 0.76 | ALDH1A1 (0.49) | FFAR4GAAMAPTHSD17B10MEN1 | |
| SCHEMBL20150022 | 0.75 | HTR1D (0.48) | FFAR4GAAMEN1KMT2AMTOR | |
| SCHEMBL7717206 | 0.74 | KDM4E (0.40) | — | |
| SCHEMBL24632953 | 0.73 | PDCD1 (0.46) | FFAR4P2RX3P2RX2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376503-B1 | TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC | 2002-04-23 | — | — | US | disclosed |
| EP-1023068-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2001-05-16 | — | — | EP | disclosed |
| EP-1023068-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-08-02 | — | — | EP | disclosed |
| WO-1998057638-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | disclosed |