Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 2/20 | 0.42 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.42 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.42 |
| ▸ | DPP4 | P27487 | 4/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | VCP | P55072 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20150022 | 0.88 | HTR1D (0.48) | CHRM4MTORRPTORMLST8DPP4 | |
| SCHEMBL7715928 | 0.85 | FFAR4 (0.39) | MTORRPTORMLST8FFAR4 | |
| SCHEMBL7715960 | 0.84 | CHRM4 (0.46) | CHRM4DPP4DPP8DPP9KDM4E | |
| SCHEMBL7716779 | 0.82 | CHRM4 (0.47) | CHRM4MTORRPTORMLST8DPP4 | |
| SCHEMBL7714987 | 0.82 | KDM4E (0.44) | CHRM4KDM4EDRD2DRD3 | |
| SCHEMBL8221478 | 0.80 | CHRM4 (0.48) | CHRM4MTORRPTORMLST8DPP4 | |
| SCHEMBL7714679 | 0.78 | CHRM4 (0.49) | CHRM4MTORRPTORMLST8DPP4 | |
| SCHEMBL21360337 | 0.78 | CHRM4 (0.43) | CHRM4DPP4FFAR4 | |
| Hydrochloric Acid SCHEMBL20141131 | 0.77 | HTT (0.43) | CHRM4DPP4FFAR4KDM4E | |
| SCHEMBL20141678 | 0.76 | CHRM4 (0.50) | CHRM4MTORRPTORMLST8DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376503-B1 | TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC | 2002-04-23 | — | — | US | disclosed |
| EP-1023068-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2001-05-16 | — | — | EP | disclosed |
| EP-1023068-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-08-02 | — | — | EP | disclosed |
| WO-1998057638-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | disclosed |