SCHEMBL7715964

SCHEMBL7715964

CCOC(=O)C(CC)C(CC)P(=O)(O)O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
ALDH1A1 P00352 6/20 0.36
LAP3 P28838 1/20 0.35
HSD17B10 Q99714 2/20 0.34
LMNA P02545 1/20 0.34
ALOX15 P16050 3/20 0.34
TSHR P16473 2/20 0.34
CYP3A4 P08684 2/20 0.34
TDP1 Q9NUW8 1/20 0.34
MGAM O43451 1/20 0.33
GAA P10253 1/20 0.33
SI P14410 1/20 0.33
MGAM2 Q2M2H8 1/20 0.33
SOAT1 P35610 1/20 0.33
POLB P06746 1/20 0.33
MMP1 P03956 2/20 0.31
MMP2 P08253 2/20 0.31
CA12 O43570 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6132143 0.80 CYP2D6 (0.41) CYP2D6CYP2C9CYP2C19ALDH1A1LAP3
SCHEMBL7718876 0.78 CYP2D6 (0.37) CYP2D6CYP2C9CYP2C19ALDH1A1LAP3
SCHEMBL235849 0.78 ALDH1A1 (0.50) ALDH1A1HSD17B10LMNAALOX15TSHR
SCHEMBL7716778 0.77 CYP2D6 (0.39) CYP2D6CYP2C9CYP2C19ALDH1A1LAP3
SCHEMBL7717041 0.77 CYP2D6 (0.39) CYP2D6CYP2C9CYP2C19ALDH1A1LAP3
SCHEMBL7714685 0.73 METAP1 (0.42) CYP2D6CYP2C9CYP2C19ALDH1A1LAP3
SCHEMBL829655 0.72 CYP2D6 (0.44) CYP2D6CYP2C9CYP2C19ALDH1A1LAP3
SCHEMBL7716775 0.72 ALDH1A1 (0.41) CYP2D6CYP2C9CYP2C19ALDH1A1LAP3
SCHEMBL8528258 0.72 CYP2D6 (0.47) CYP2D6CYP2C9CYP2C19ALDH1A1LAP3
SCHEMBL13575648 0.72 ALDH1A1 (0.43) CYP2C19ALDH1A1HSD17B10LMNAALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115536719-A Synthetic method of high-purity plant source 7-ketolithocholic acid 江苏佳尔科药业集团股份有限公司 2022-12-30 CN disclosed
CN-115246867-A Method for synthesizing 7-ketolithocholic acid by taking BA as raw material 江苏佳尔科药业集团股份有限公司 2022-10-28 CN disclosed
US-6376512-B1 FOR TREATING PHYSIOLOGICAL CONDITION IN PATIENT WHEREIN SAID CONDITION IS ASSOCIATED WITH A PHYSIOLOGICALLY DETRIMENTAL LEVELS OF INSULIN, GLUCOSE, FREE FATTY ACIDS, OR TRIGLYCERIDES AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2002-04-23 US disclosed
EP-0315399-B1 Quinoline derivatives, their use in the treatment of hypersensitive ailments and a pharmaceutical composition containing the same RHONE POULENC RORER INT (US) 1996-01-10 EP disclosed
US-5059610-A QUINOLINE DERIVATIVES AND THEIR USE AS ANTAGONISTS OF LEUKOTRIENE D4 RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1991-10-22 US disclosed
US-4920132-A Quinoline derivatives and use thereof as antagonists of leukotriene D4 RORER PHARMACEUTICAL CORP. (US) 1990-04-24 US disclosed