Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7716629 | 0.81 | PIK3CA (0.54) | POLBKDM4EMAPTGAARECQL | |
| SCHEMBL7714388 | 0.70 | POLB (0.50) | POLBMAPTMAPK1HRH4LMNA | |
| SCHEMBL16652492 | 0.68 | MAPT (0.69) | POLBADRA2CKDM4EMAPTGAA | |
| SCHEMBL28324074 | 0.68 | DHFR (0.65) | HRH4 | |
| SCHEMBL20831227 | 0.68 | POLB (0.68) | POLBLMNAKMT2ASMN1; SMN2CYP3A4 | |
| SCHEMBL21698793 | 0.67 | KDM4E (0.47) | POLBADRA2CKDM4EMAPTGAA | |
| SCHEMBL162683 | 0.65 | — | — | |
| SCHEMBL16040218 | 0.65 | ADRA2C (0.53) | POLBADRA2CKDM4EMAPTGAA | |
| SCHEMBL17758355 | 0.65 | KDM4E (0.49) | POLBADRA2CKDM4EMAPTGAA | |
| SCHEMBL16039371 | 0.65 | ADRA2C (0.58) | POLBADRA2CKDM4EMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6440965-B1 | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system | KRENITSKY PHARMACEUTICALS, INC. | 2002-08-27 | — | — | US | disclosed |