Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 3/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7712513 | 0.85 | HRH4 (0.49) | KMT2AMEN1CSF1RHSD17B10CCNC | |
| SCHEMBL7714150 | 0.72 | MEN1 (0.61) | KMT2AMEN1NPSR1HTTTSHR | |
| SCHEMBL5202998 | 0.72 | LTA4H (0.57) | KMT2AMEN1CCNCCDK8HPGD | |
| SCHEMBL5207646 | 0.72 | KDM4C (0.41) | KMT2AMEN1HTTCCNCCDK8 | |
| SCHEMBL7714247 | 0.72 | MEN1 (0.53) | KMT2AMEN1NPSR1HTTCCNC | |
| SCHEMBL30766045 | 0.70 | KMT2A (0.51) | KMT2AMEN1TSHRHSD17B10MAPK1 | |
| SCHEMBL7708436 | 0.69 | LMNA (0.52) | NPSR1CCNCCDK8MAPK1LTA4H | |
| SCHEMBL7716750 | 0.69 | KDM4C (0.40) | KMT2AMEN1NPSR1HTTCSF1R | |
| SCHEMBL8156197 | 0.68 | MEN1 (0.48) | KMT2AMEN1NPSR1HTTMAPK1 | |
| SCHEMBL7714712 | 0.68 | KMT2A (0.54) | KMT2AMEN1NPSR1HTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6440965-B1 | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system | KRENITSKY PHARMACEUTICALS, INC. | 2002-08-27 | — | — | US | disclosed |