Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Hexamethonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 4/20 | 0.92 |
| ▸ | MEN1 | O00255 | 4/20 | 0.92 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.92 |
| ▸ | APEX1 | P27695 | 3/20 | 0.92 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.92 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.92 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.92 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.92 |
| ▸ | LMNA | P02545 | 2/20 | 0.92 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.92 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.92 |
| ▸ | TSHR | P16473 | 1/20 | 0.92 |
| ▸ | RAB9A | P51151 | 1/20 | 0.92 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.85 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.75 |
| ▸ | APAF1 | O14727 | 1/20 | 0.61 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.61 |
| ▸ | RAD52 | P43351 | 1/20 | 0.61 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.45 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Decamethonium SCHEMBL2125690 | 1.00 | MEN1 (0.92) | MEN1KMT2AACHEAPEX1NFKB1 | |
| Decamethonium SCHEMBL2126026 | 1.00 | MEN1 (0.92) | MEN1KMT2AACHEAPEX1NFKB1 | |
| Pentamethonium SCHEMBL1981108 | 1.00 | MEN1 (0.92) | MEN1KMT2AACHEAPEX1NFKB1 | |
| Decamethonium SCHEMBL2127335 | 1.00 | MEN1 (0.92) | MEN1KMT2AACHEAPEX1NFKB1 | |
| Decamethonium SCHEMBL2128894 | 1.00 | MEN1 (0.92) | MEN1KMT2AACHEAPEX1NFKB1 | |
| Decamethonium SCHEMBL238400 | 0.96 | MEN1 (1.00) | MEN1KMT2AACHEAPEX1NFKB1 | |
| SCHEMBL12126378 | 0.96 | MEN1 (1.00) | MEN1KMT2AACHEAPEX1NFKB1 | |
| SCHEMBL6933263 | 0.96 | MEN1 (1.00) | MEN1KMT2AACHEAPEX1NFKB1 | |
| Pentamethonium SCHEMBL61798 | 0.96 | MEN1 (1.00) | MEN1KMT2AACHEAPEX1NFKB1 | |
| SCHEMBL17898630 | 0.96 | MEN1 (1.00) | MEN1KMT2AACHEAPEX1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4742866-A1 | PEROVSKITE SOLAR CELL AND PREPARATION METHOD THEREFOR, PHOTOVOLTAIC MODULE, SYSTEM, AND ELECTRIC DEVICE | Contemporary Amperex Future Energy Research Institute (Shanghai) Limited (CN) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025011160-A1 | PEROVSKITE SOLAR CELL AND PREPARATION METHOD THEREFOR, PHOTOVOLTAIC MODULE, SYSTEM, AND ELECTRIC DEVICE | 宁德时代未来能源(上海)研究院有限公司 | 2025-01-16 | — | — | WO | disclosed |
| CN-119317296-A | Perovskite solar cell, preparation method thereof, photovoltaic module, system and electricity utilization device | 宁德时代未来能源(上海)研究院有限公司 | 2025-01-14 | — | — | CN | disclosed |
| WO-2022092310-A1 | COMPOUND, ALDEHYDE DEHYDROGENASE 2 ACTIVATOR, PHARMACEUTICAL COMPOSITION, AND TREATMENT AND/OR PREVENTATIVE DRUG | 株式会社アークメディスン | 2022-05-05 | — | — | WO | disclosed |
| CN-109704358-B | Synthesis method of EU-1/ZSM-5 composite molecular sieve | 中国石油化工股份有限公司 | 2021-05-11 | — | — | CN | disclosed |
| CN-109704356-B | Method for synthesizing EU-1 zeolite molecular sieve | 中国石油化工股份有限公司 | 2021-05-11 | — | — | CN | disclosed |
| US-6337063-B1 | REACTING AQUEOUS MIXTURE OF SOURCES OF ELEMENTS THAT FORM ZEOLITE AND MONOAMINE PRECURSOR OF ALKYLATED POLYMETHYLENE .ALPHA.-.OMEGA. DIAMMONIUM DERIVATIVE TO FORM ZEOLITE | INSTITUT FRANCAIS DU PETROLE (FR) | 2002-01-08 | — | — | US | disclosed |
| US-3932189-A | Thermodevelopable photographic material containing high silver ion conducting substance | FUJI PHOTO FILM CO., LTD. (JA) | 1976-01-13 | — | — | US | disclosed |