Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.49 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.47 |
| ▸ | RARA | P10276 | 2/20 | 0.46 |
| ▸ | RARB | P10826 | 2/20 | 0.46 |
| ▸ | RARG | P13631 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | BLVRB | P30043 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4405727 | 0.95 | CRBN (0.65) | CRBNKMT2ACTDSP1PTPN1GAA | |
| SCHEMBL4415749 | 0.92 | TLK2 (0.56) | CRBNKMT2AGAATLK2SMYD3 | |
| SCHEMBL5842454 | 0.83 | TLK2 (0.57) | PTPN1GAATLK2SMYD3RAB9A | |
| SCHEMBL26547572 | 0.82 | SMYD3 (0.56) | CRBNTLK2SMYD3LRRK2HDAC3 | |
| SCHEMBL688478 | 0.80 | CRBN (0.58) | CRBNGAASMYD3HDAC3 | |
| SCHEMBL29779535 | 0.80 | CRBN (0.58) | CRBNGAASMYD3HDAC3 | |
| SCHEMBL1663776 | 0.79 | TLK2 (0.53) | CRBNGAATLK2SMYD3LRRK2 | |
| SCHEMBL23175704 | 0.78 | LMNA (0.57) | CRBNGAATLK2SMYD3RAB9A | |
| SCHEMBL29899570 | 0.78 | LMNA (0.57) | CRBNGAATLK2SMYD3RAB9A | |
| SCHEMBL22424906 | 0.78 | RAB9A (0.57) | CRBNKMT2ASMYD3MEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1233943-A2 | IONIZABLE INDOLINONE DERIVATIVES AND THEIR USE AS PTK LIGANDS | Sugen, Inc. (US) | 2002-08-28 | — | — | EP | disclosed |
| WO-2001037820-A2 | IONIZABLE INDOLINONE DERIVATIVES AND THEIR USE AS PTK LIGANDS | SUGEN, INC. (US) | 2001-05-31 | — | — | WO | disclosed |