Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 10/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5166395 | 0.92 | TP53 (0.47) | EGFRGPBAR1MEN1KMT2APGR | |
| SCHEMBL7600507 | 0.87 | MEN1 (0.47) | EGFRGPBAR1MEN1KMT2APGR | |
| SCHEMBL5167604 | 0.84 | MEN1 (0.55) | EGFRGPBAR1MEN1KMT2APGR | |
| SCHEMBL7718082 | 0.79 | MEN1 (0.45) | EGFRMEN1KMT2APGRTP53 | |
| SCHEMBL19114836 | 0.79 | TP53 (0.51) | EGFRGPBAR1MEN1KMT2APGR | |
| Laquinimod SCHEMBL39440 | 0.78 | TP53 (0.50) | EGFRGPBAR1MEN1KMT2APGR | |
| Laquinimod SCHEMBL29438575 | 0.78 | TP53 (0.50) | EGFRGPBAR1MEN1KMT2APGR | |
| Laquinimod SCHEMBL1573337 | 0.77 | TP53 (0.49) | EGFRGPBAR1MEN1KMT2APGR | |
| SCHEMBL19628902 | 0.77 | MEN1 (0.48) | MEN1KMT2APGRTP53MAP3K5 | |
| SCHEMBL19114839 | 0.77 | TP53 (0.49) | EGFRGPBAR1MEN1KMT2APGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6395750-B1 | Includes laquinimod, N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxamide and its salts; breat or prostate cancer | ACTIVE BIOTECH AB (SE) | 2002-05-28 | — | — | US | disclosed |