Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7721826 | 0.84 | PTPN1 (0.58) | BRD4ALDH1A1KMT2AMEN1NR1I2 | |
| SCHEMBL7163100 | 0.82 | MAPT (0.58) | BRD4ALDH1A1HSD17B10KMT2AMEN1 | |
| SCHEMBL7721484 | 0.80 | RXFP1 (0.56) | BRD4KMT2AMEN1NR1I2LMNA | |
| SCHEMBL7726031 | 0.80 | RXFP1 (0.53) | BRD4ALDH1A1KMT2AMEN1NR1I2 | |
| SCHEMBL3352936 | 0.80 | LMNA (0.79) | KDM4EALDH1A1KMT2AMEN1NR1I2 | |
| Hydrochloric Acid SCHEMBL1239153 | 0.78 | LMNA (0.77) | KDM4EALDH1A1KMT2AMEN1NR1I2 | |
| Hydrochloric Acid SCHEMBL7831044 | 0.78 | LMNA (0.77) | KDM4EALDH1A1KMT2AMEN1NR1I2 | |
| SCHEMBL7167278 | 0.78 | MAPT (0.53) | BRD4ALDH1A1KMT2AMEN1NR1I2 | |
| SCHEMBL15528360 | 0.78 | HTT (0.60) | ALDH1A1HPGDKMT2AMEN1LMNA | |
| SCHEMBL7960802 | 0.77 | MEN1 (0.64) | KDM4EALDH1A1HPGDHSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6391885-B1 | CONTROLLING APOPTOSIS IN AUTOIMMUNE DISEASE | CELL PATHWAYS, INC. | 2002-05-21 | — | — | US | disclosed |
| US-6060477-A | Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives | CELL PATHWAYS, INC. (US) | 2000-05-09 | — | — | US | disclosed |
| EP-0347146-B1 | FUSED PYRIMIDINE DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-09-01 | — | — | EP | disclosed |
| US-5047404-A | Fused pyrimidine derivatives bronchodilator agents, antiallergens | SMITH KLINE & FRENCH LABORATORIES, LTD. (GB) | 1991-09-10 | — | — | US | disclosed |
| EP-0347146-A2 | Fused pyrimidine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-12-20 | — | — | EP | disclosed |