Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7163100 | 0.81 | MAPT (0.58) | MEN1KMT2AMAPTNPC1ALDH1A1 | |
| SCHEMBL3352936 | 0.79 | LMNA (0.79) | MEN1KMT2AKDM4EMAPTALDH1A1 | |
| SCHEMBL17274993 | 0.78 | MAPK1 (0.81) | HPGDNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL15528701 | 0.78 | L3MBTL1 (0.69) | MEN1KMT2AHPGDKDM4EMAPT | |
| Hydrochloric Acid SCHEMBL1239153 | 0.77 | LMNA (0.77) | MEN1KMT2AKDM4EMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL7831044 | 0.77 | LMNA (0.77) | MEN1KMT2AKDM4EMAPTALDH1A1 | |
| SCHEMBL7167278 | 0.77 | MAPT (0.53) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL7718074 | 0.77 | BRD4 (0.55) | MEN1KMT2AHPGDKDM4EMAPT | |
| SCHEMBL16464436 | 0.76 | MEN1 (0.69) | MEN1KMT2AMAPTALDH1A1NR1I2 | |
| Oxalic Acid SCHEMBL27771077 | 0.75 | LMNA (0.72) | MEN1KMT2AKDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200980-B1 | ADMINISTERING PHENYL PURINONE COMPOUND FOR TREATING PRECANCEROUS LEISONS | CELL PATHWAYS, INC. | 2001-03-13 | — | — | US | disclosed |
| EP-0349239-B1 | Condensed pyrimidine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | SMITH KLINE FRENCH LAB (GB) | 1994-03-16 | — | — | EP | disclosed |
| US-5075310-A | PYRIMIDONE DERIVATIVES AS BRONCHODILATORS | SMITH KLINE & FRENCH LABORATORIES, LTD. (GB) | 1991-12-24 | — | — | US | disclosed |
| EP-0349239-A2 | Condensed pyrimidine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-01-03 | — | — | EP | disclosed |