Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7717188 | 0.87 | TSHR (0.35) | ACHETSHRPOLBTP53TDP1 | |
| SCHEMBL7710940 | 0.81 | ACHE (0.38) | ACHETSHRPOLBTP53TDP1 | |
| SCHEMBL7718842 | 0.80 | ACHE (0.31) | ACHE | |
| SCHEMBL7716022 | 0.79 | TSHR (0.39) | ACHETSHRPOLBTP53TDP1 | |
| SCHEMBL9022468 | 0.79 | KMT2A (0.37) | ACHETSHRPOLBTDP1MEN1 | |
| SCHEMBL14010336 | 0.78 | TSHR (0.40) | TSHRPOLBTP53TDP1L3MBTL1 | |
| SCHEMBL26075699 | 0.78 | TSHR (0.40) | TSHRPOLBTP53TDP1L3MBTL1 | |
| SCHEMBL7716708 | 0.77 | POLB (0.43) | POLBL3MBTL1MEN1KMT2A | |
| SCHEMBL26075702 | 0.76 | TSHR (0.39) | TSHRPOLBTP53TDP1L3MBTL1 | |
| SCHEMBL27744277 | 0.73 | FDPS (0.41) | TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376512-B1 | FOR TREATING PHYSIOLOGICAL CONDITION IN PATIENT WHEREIN SAID CONDITION IS ASSOCIATED WITH A PHYSIOLOGICALLY DETRIMENTAL LEVELS OF INSULIN, GLUCOSE, FREE FATTY ACIDS, OR TRIGLYCERIDES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-04-23 | — | — | US | disclosed |
| EP-0315399-B1 | Quinoline derivatives, their use in the treatment of hypersensitive ailments and a pharmaceutical composition containing the same | RHONE POULENC RORER INT (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5059610-A | QUINOLINE DERIVATIVES AND THEIR USE AS ANTAGONISTS OF LEUKOTRIENE D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-10-22 | — | — | US | disclosed |
| US-4920132-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |